The search for anti-oxytotic/ferroptotic compounds in the plant world.
The search for anti-oxytotic/ferroptotic compounds in the plant world.
复制标题
在植物界寻找抗氧化/吸铁化合物。
DOI：
10.1111/bph.15517
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发表时间：
2021-09
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
氧中毒/铁中毒是一种非凋亡调节的细胞死亡形式，其特征是谷胱甘肽（GSH）耗竭和线粒体ROS产生失调，导致致命的脂质过氧化。随着氧中毒/铁下垂对年龄相关人类疾病的重要性开始被认识到，开发创新方法来确定针对氧中毒/铁下垂途径的新疗法是再及时不过的了。由于植物的无根性，它们会暴露在各种各样的压力下，这些压力会引发类似于氧中毒/铁中毒的生理变化。因此，它们进化出了一系列丰富的化学策略来应对这些具有挑战性的条件。这篇综述详细介绍了一种药物发现方法，用于从植物中识别治疗阿尔茨海默病和相关痴呆的有效的氧下沉/铁下沉抑制剂，从而强调了基于植物的研究在开发新药的同时也是可持续发展的催化剂的巨大潜力。
Oxytosis/ferroptosis is a form of non-apoptotic regulated cell death characterized by glutathione (GSH) depletion and dysregulated production of mitochondrial ROS that results in lethal lipid peroxidation. As the significance of oxytosis/ferroptosis to age-associated human diseases is now beginning to be appreciated, the development of innovative approaches to identify novel therapeutics that target the oxytosis/ferroptosis pathway could not be more timely. Due to their sessile nature, plants are exposed to a variety of stresses that trigger physiological changes similar to those found in oxytosis/ferroptosis. As such, they have evolved a rich array of chemical strategies to deal with those challenging conditions. This review details a drug discovery approach for identifying potent inhibitors of oxytosis/ferroptosis from plants for the treatment of Alzheimer’s disease and related dementias, thereby highlighting the tremendous potential of plant-based research for developing new medicines while simultaneously being a catalyst for sustainability.
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DOI：
10.18632/aging.100838
发表时间：
2015-11
期刊：
Aging
影响因子：
--
作者：
Currais A;Goldberg J;Farrokhi C;Chang M;Prior M;Dargusch R;Daugherty D;Armando A;Quehenberger O;Maher P;Schubert D
通讯作者：
Schubert D
影响因子：
7.8
作者：
Currais A;Prior M;Dargusch R;Armando A;Ehren J;Schubert D;Quehenberger O;Maher P
通讯作者：
Maher P
影响因子：
21.3
作者：
Friedmann Angeli JP;Schneider M;Proneth B;Tyurina YY;Tyurin VA;Hammond VJ;Herbach N;Aichler M;Walch A;Eggenhofer E;Basavarajappa D;Rådmark O;Kobayashi S;Seibt T;Beck H;Neff F;Esposito I;Wanke R;Förster H;Yefremova O;Heinrichmeyer M;Bornkamm GW;Geissler EK;Thomas SB;Stockwell BR;O'Donnell VB;Kagan VE;Schick JA;Conrad M
通讯作者：
Conrad M
影响因子：
7.3
作者：
Chiruta, Chandramouli;Schubert, David;Dargusch, Richard;Maher, Pamela
通讯作者：
Maher, Pamela
影响因子：
16
作者：
Atanasov AG;Waltenberger B;Pferschy-Wenzig EM;Linder T;Wawrosch C;Uhrin P;Temml V;Wang L;Schwaiger S;Heiss EH;Rollinger JM;Schuster D;Breuss JM;Bochkov V;Mihovilovic MD;Kopp B;Bauer R;Dirsch VM;Stuppner H
通讯作者：
Stuppner H