[Thermal radiosensitization in vitro and its implication to radiotherapy].
[Thermal radiosensitization in vitro and its implication to radiotherapy].
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体外热放射增敏及其对放射治疗的意义[J].
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
M. Urano
中科院分区：
文献类型：
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作者：
H. Majima;M. Urano
本文综述了热辐射增敏作用及其可能的机制。体外研究表明，与辐射克隆后的存活率相比，高温可以增强辐射对细胞的杀伤，导致细胞存活曲线的斜率更陡，肩部更小。分子生物学研究表明，高温抑制DNA合成和/或修复DNA损伤可能是热辐射增敏的主要原因。当曲线用线性二次（L-Q）模型拟合时，对于辐射结合热疗的存活曲线，β值的数量增加，而α值的数量相对稳定。这意味着当较大的辐射剂量（大于或等于4戈伊）与热疗组合时，在热放疗中增强将更大。
Thermal radiosensitization and the possible mechanism are reviewed. In vitro studies suggest that hyperthermia can enhance cell killing by radiation resulting in a steeper slope and smaller shoulder of the cell survival curve, compared to the survival were following radiation clone. Molecular studies suggest that inhibition of DNA synthesis and or repair of DNA damage by hyperthermia might be major causes of the thermal radiosensitization. When the curve is fitted by linar quadratic (L-Q) model, a increased number of beta, while relatively stable amount of alpha values are shown for survival curve to radiation combined with hyperthermia. This implies that when a larger radiation dose (greater than or equal to 4 Gy) is combined with hyperthermia, the enhancement would be greater in thermal radiotherapy.