Objective and subjective breast cancer risk: relationships with natural killer cell activity and psychological distress in healthy women.
Objective and subjective breast cancer risk: relationships with natural killer cell activity and psychological distress in healthy women.
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DOI：
10.1097/ncc.0b013e3181dc37a1
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发表时间：
2010-11
期刊：
影响因子：
2.6
通讯作者：
Weaver MT
中科院分区：
文献类型：
--
作者：
Park NJ;Kang DH;Weaver MT
乳腺癌（BC）风险，基于已知的风险因素（客观）或自我评估（主观），可能直接或通过心理困扰影响自然杀伤细胞活性（NKCA）。本研究的主要目的是探讨客观和主观的BC风险与NKCA的关系和心理困扰的中介作用，在社区样本的健康妇女。在一项横断面描述性研究中，117名健康女性（平均年龄36.5岁）完成了BC风险和心理困扰的问卷调查，并提供了NKCA测量的血液。客观和主观BC风险呈正相关（p <0.001）。回归分析显示，在12.5：1的效应细胞与靶细胞（E：T）比值下，客观BC风险与NKCA呈显著负相关（p = 0.011），而在任何E：T细胞比值下，主观风险与NKCA均不相关。只有主观风险与BC特异性（p = 0.002）和一般（p <0.001）心理困扰呈正相关。心理困扰未能调解主观风险和NKCA之间的关系。目的BC风险与NKCA有有限但显著的关系。主观风险与心理困扰高度相关，但与NKCA无关。尽管BC风险和NKCA之间的关系有限，但BC风险对其他肿瘤防御机制的影响需要进一步探讨。这一领域的集体研究结果将为监测BC风险和维持健康女性更好的肿瘤防御提供早期预防策略。
Breast cancer (BC) risk, based on either known risk factors (objective) or self-assessment (subjective), may influence natural killer cell activity (NKCA) directly or through psychological distress. The main objective of this study was to examine the relationships of objective and subjective BC risk with NKCA and a mediating role of psychological distress in a community sample of healthy women. In a cross-sectional descriptive study, a convenience sample of 117 healthy women (mean age 36.5 years) completed questionnaires for BC risk and psychological distress and provided blood for NKCA measurement. Objective and subjective BC risk were positively correlated (p < .001). Regression analyses revealed that objective BC risk had a significant negative relationship with NKCA at the 12.5:1 effector-to-target (E:T) cell ratio (p = .011), whereas subjective risk was not associated with NKCA at any E:T cell ratio tested. Only subjective risk had a positive association with both BC-specific (p = .002) and general (p < .001) psychological distress. Psychological distress failed to mediate the relationship between subjective risk and NKCA. Objective BC risk had a limited but significant relationship with NKCA. Subjective risk was highly associated with psychological distress but was not associated with NKCA. Despite the limited relationships between BC risk and NKCA, the impact of BC risk on other tumor defense mechanisms needs to be further explored. Collective findings in this area will suggest early preventive strategies for monitoring BC risk and maintaining better tumor defense in healthy women.