Ecological Analysis of the Decline in Incidence Rates of COVID-19 Among Nursing Home Residents Associated with Vaccination, United States, December 2020-January 2021.
Ecological Analysis of the Decline in Incidence Rates of COVID-19 Among Nursing Home Residents Associated with Vaccination, United States, December 2020-January 2021.
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DOI：
10.1016/j.jamda.2021.08.004
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发表时间：
2021-10
影响因子：
7.6
通讯作者：
NHSN Team
中科院分区：
文献类型：
--
作者：
Benin AL;Soe MM;Edwards JR;Bagchi S;Link-Gelles R;Schrag SJ;Herzer K;Verani JR;Budnitz D;Nanduri S;Jernigan J;Edens C;Gharpure R;Patel A;Wu H;Golshir BC;Jaffe A;Li Q;Srinivasan A;Shulman E;Ling SM;Moody-Williams J;Fleisher LA;Pollock DA;Bell J;NHSN Team
为了评估在养老院居民中，在经过其他因素调整后的2021年1月，在最初的疫苗接种诊所之后进行设施水平的疫苗接种是否与新冠肺炎的发病率独立相关。对来自疾控中心国家医疗安全网络(NHSN)和疾控中心长期护理计划药房伙伴关系的数据进行生态分析。CMS认证的疗养院同时参加NHSN和长期护理药房合作伙伴计划。应用多变量、随机截取、负二项模型，比较在截至2021年1月3日的一周内，居住在有初始疫苗接种诊所的设施中的居民(n=2843)和在截至2021年1月10日的一周(包括该周)未报告疫苗接种诊所的居民中的新冠肺炎发病率(n=3216)。模型协变量包括床位大小、居民SARS-CoV-2检测、新冠肺炎工作人员、居民累积新冠肺炎、新冠肺炎住院居民、社区县发病率和县社会脆弱性指数。2020年12月和2021年1月，养老院居民中新冠肺炎的发病率降至5月份开始报告以来的最低点，与社区病例的模式背道而驰，并在接种疫苗之前开始下降。比较初始接种诊所后的第三周和第二周，已接种疫苗机构的新冠肺炎调整后降幅比尚未接种诊所的机构的降幅高27%(95%可信区间：14%-38%，P<；0.05)。居民接种疫苗有助于养老院新冠肺炎发病率的下降；然而，其他因素也起到了作用。新冠肺炎的下降在广泛接种疫苗之前就很明显，突显了多面预防方法的好处，包括继续使用推荐的筛查、检测和感染预防做法，以及接种疫苗，以确保疗养院居民的安全。
To evaluate if facility-level vaccination after an initial vaccination clinic was independently associated with COVID-19 incidence adjusted for other factors in January 2021 among nursing home residents. Ecological analysis of data from the CDC's National Healthcare Safety Network (NHSN) and from the CDC's Pharmacy Partnership for Long-Term Care Program. CMS-certified nursing homes participating in both NHSN and the Pharmacy Partnership for Long-Term Care Program. A multivariable, random intercepts, negative binomial model was applied to contrast COVID-19 incidence rates among residents living in facilities with an initial vaccination clinic during the week ending January 3, 2021 (n = 2843), vs those living in facilities with no vaccination clinic reported up to and including the week ending January 10, 2021 (n = 3216). Model covariates included bed size, resident SARS-CoV-2 testing, staff with COVID-19, cumulative COVID-19 among residents, residents admitted with COVID-19, community county incidence, and county social vulnerability index (SVI). In December 2020 and January 2021, incidence of COVID-19 among nursing home residents declined to the lowest point since reporting began in May, diverged from the pattern in community cases, and began dropping before vaccination occurred. Comparing week 3 following an initial vaccination clinic vs week 2, the adjusted reduction in COVID-19 rate in vaccinated facilities was 27% greater than the reduction in facilities where vaccination clinics had not yet occurred (95% confidence interval: 14%-38%, P < .05). Vaccination of residents contributed to the decline in COVID-19 incidence in nursing homes; however, other factors also contributed. The decline in COVID-19 was evident prior to widespread vaccination, highlighting the benefit of a multifaced approach to prevention including continued use of recommended screening, testing, and infection prevention practices as well as vaccination to keep residents in nursing homes safe.
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DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
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作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
DOI：
10.15585/mmwr.mm6912e2
发表时间：
2020-03-27
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
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作者：
CDC COVID-19 Response Team
通讯作者：
CDC COVID-19 Response Team
影响因子：
4.9
作者：
Dick, Andrew W.;Bell, Jeneita M.;Stone, Patricia W.
通讯作者：
Stone, Patricia W.
DOI：
10.15585/mmwr.mm6912e1
发表时间：
2020-03-27
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
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作者：
McMichael TM;Clark S;Pogosjans S;Kay M;Lewis J;Baer A;Kawakami V;Lukoff MD;Ferro J;Brostrom-Smith C;Riedo FX;Russell D;Hiatt B;Montgomery P;Rao AK;Currie DW;Chow EJ;Tobolowsky F;Bardossy AC;Oakley LP;Jacobs JR;Schwartz NG;Stone N;Reddy SC;Jernigan JA;Honein MA;Clark TA;Duchin JS;Public Health – Seattle & King County, EvergreenHealth, and CDC COVID-19 Investigation Team
通讯作者：
Public Health – Seattle & King County, EvergreenHealth, and CDC COVID-19 Investigation Team