A common ancestry for BAP1 and Uch37 regulators
A common ancestry for BAP1 and Uch37 regulators
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DOI：
10.1093/bioinformatics/bts319
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发表时间：
2012-08-01
期刊：
影响因子：
5.8
通讯作者：
Ponting, Chris P.
中科院分区：
文献类型：
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作者：
Sanchez-Pulido, Luis;Kong, Lesheng;Ponting, Chris P.
为了揭示多梳抑制去泛素酶（PR-DUB）复合体如何控制底物选择特异性，我们对其组成部分进行了详细的计算序列分析：额外的性梳如1 （ASXL1）和brca1相关蛋白1 （BAP1）蛋白。这导致在ASXL1中发现了两个以前未被识别的结构域：叉头（翼螺旋）dna结合结构域和去泛素酶适配器结构域，它们与泛素羧基末端水解酶37 （Uch37）的两个调节因子共享，即粘附调节分子1 （ADRM1）和与kappaB相关的核因子（NFRKB）。我们的分析表明，在PR-DUB、INO80染色质重塑和蛋白体复合物中，BAP1和Uch37调节因子具有共同的祖先。
To reveal how the polycomb repressive-deubiquitinase (PR-DUB) complex controls substrate selection specificity, we undertook a detailed computational sequence analysis of its components: additional sex combs like 1 (ASXL1) and BRCA1-associated protein 1 (BAP1) proteins. This led to the discovery of two previously unrecognized domains in ASXL1: a forkhead (winged-helix) DNA-binding domain and a deubiquitinase adaptor domain shared with two regulators of ubiquitin carboxyl-terminal hydrolase 37 (Uch37), namely adhesion regulating molecule 1 (ADRM1) and nuclear factor related to kappaB (NFRKB). Our analysis demonstrates a common ancestry for BAP1 and Uch37 regulators in PR-DUB, INO80 chromatin remodelling and proteosome complexes.