SURVIVAL OF TRANSPLANTED OVARIES IN RATS
SURVIVAL OF TRANSPLANTED OVARIES IN RATS
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DOI：
10.1002/jez.1401120110
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发表时间：
1949-01-01
影响因子：
--
通讯作者：
EAKIN, RM
中科院分区：
文献类型：
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作者：
HARRIS, M;EAKIN, RM
大鼠卵巢移植已被用于分析导致破坏和消除来自外来宿主的移植的因素。五个系列的移植物进行了研究，移植物和宿主之间的遗传差异系统地从自体，通过兄弟姐妹，菌株内，同质，异质关系。在每个系列中研究了宿主卵巢切除术的影响，因为它影响移植物的再生和修复、白细胞和结缔组织的浸润以及在陌生环境中的存活。自体移植物在卵巢切除和非卵巢切除的宿主中几乎总是成功的;异种移植物（小鼠卵巢）总是退化的。在其余的系列，卵巢切除术的主机一贯倾向于强调再生和延迟或防止破坏移植物在一个陌生的环境。移植物和宿主之间没有明显的不相容性迹象，直到术后5-7天，当许多移植物迅速被破坏时。在显示活跃再生的移植物中，退行性变化的发生延迟数周或数月。在某些情况下，不相关品系大鼠之间的卵巢同种移植物存活至少3个月。这些数据与获得性免疫作为宿主拮抗作用基础的概念一致。他们不支持勒布的有机体差异理论。这表明，移植的细胞可以生存在一个陌生的环境中，尽管存在的免疫体通过中和或灭活这些物质。
Ovarian grafts in rats have been used for an analysis of factors leading to the destruction and elimination of transplants from alien hosts. Five series of grafts were studied with the genetic differential between graft and host varying systematically from an autogenous, through sibling, intra-strain, and homogenous, to a heterogenous relationship. The effect of ovari-ectomy of the host was studied in each series as it affected regeneration and repair of the graft, infiltration of leukocytes and connective tissue, and survival in an alien environment. Autografts nearly always succeeded in both ovariectomized and non- ovariectomized hosts; heterografts (mouse ovaries) invariably retrogressed. In the remaining series, ovariectomy of the host consistently tended to accentuate regeneration and to delay or prevent the destruction of grafts in an alien environment. No sign of incompatibility was evident between graft and host until 5-7 days after operation, when many grafts were rapidly destroyed. In grafts showing active regeneration the onset of degenerative changes was delayed for weeks or months. Homografts of ovary between unrelated strains of rats in some instances survived in good condition for at least 3 mos. These data are consistent with the concept of acquired immunity as a basis for host antagonism. They do not support Loeb''s theory of organismal differentials. It is suggested that transplanted cells may survive in an alien environment despite the presence of immune bodies by means of a neutralization or inactivation of these substances.