GAMMA-VINYL-GABA - A SINGLE-BLIND TRIAL IN PATIENTS WITH EPILEPSY
GAMMA-VINYL-GABA - A SINGLE-BLIND TRIAL IN PATIENTS WITH EPILEPSY
复制标题
DOI：
10.1111/j.1600-0404.1983.tb04812.x
复制
发表时间：
1983-01-01
影响因子：
3.5
通讯作者：
DAM, M
中科院分区：
文献类型：
--
作者：
GRAM, L;LYON, BB;DAM, M
γ的抗癫痫作用采用安慰剂对照、单盲设计，在15例难治性癫痫患者中研究了乙烯基-GABA（GVG），大多数患者发生复杂部分性癫痫发作。将GVG加入伴随治疗中，保持恒定的血清水平。以1、2和3 g/天剂量给药后，观察到癫痫发作频率显著降低。血清GVG水平与临床疗效相关性较差。仅观察到轻微和短暂的副作用。
The anti-epileptic effect of .gamma.-vinyl-GABA (GVG) was studied using a placebo-controlled, single-blind design in 15 patients with therapy-resistant epilepsy, the majority experiencing complex partial seizures. GVG was added to concomitant treatment, which was kept at constant serum levels. Following administration of 1, 2 and 3 g/day, significant reductions in seizure frequency were observed. A poor correlation was found between GVG serum levels and clinical effect. Only mild and transient side-effects were observed.