Giardiasis, drug resistance, and new target discovery.
Giardiasis, drug resistance, and new target discovery.
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DOI：
10.2174/187152610791591629
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发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
Hai-Feng Tian;Bing Chen;J. Wen
中科院分区：
文献类型：
--
作者：
Hai-Feng Tian;Bing Chen;J. Wen
贾第虫病是一种世界范围内的寄生虫病，由人类和其他动物，特别是牲畜中的原生动物贾第虫引起。在这里，我们简要回顾一下贾第虫病的治疗现状，包括化学药物和疫苗，以及预防和治疗该病的困境，包括耐药性的出现和疫苗（特别是人类疫苗）的短缺。今后在控制贾第虫病方面的努力和进展可从三个方面进行：阐明耐药机制、开发高效疫苗、确定更多的新药和疫苗靶点。
Giardiasis is a worldwide parasitic disease caused by the protozoan Giardia lamblia in humans and other animals, especially live stocks. Here, we briefly review the current state of therapeutic availability for giardiasis, including chemical drugs and vaccines, and the dilemma in the prevention and treatment of this disease, including the emergence of drug resistance and the shortage of vaccine (especially for humans). Future efforts and progress in controlling giardiasis are expected in three aspects: clarification of the drug resistance mechanisms, development of efficient vaccines, and identification of more targets for new drugs and vaccines.