RISE OF BLOOD-PRESSURE WITH AGE - NEW EVIDENCE OF POPULATION DIFFERENCES
RISE OF BLOOD-PRESSURE WITH AGE - NEW EVIDENCE OF POPULATION DIFFERENCES
复制标题
DOI：
10.1161/01.hyp.24.6.779
复制
发表时间：
1994-12-01
期刊：
影响因子：
8.3
通讯作者：
LOPEZGOMEZ, J
中科院分区：
文献类型：
--
作者：
RODRIGUEZ, BL;LABARTHE, DR;LOPEZGOMEZ, J
Epstein和Eckoff在1967年设计了一个方案，根据收缩压的斜率和水平，总结不同年龄收缩压平均值升高的人群差异。这是第一次，该计划的有效性可以检查从一个单一的研究，INTERSALT的数据。这项研究包括32个国家的52个人群。在这些数据的基础上，收集在一个非常良好的标准化模式下的一个共同的协议，多样性的人群中的年龄差异的斜率收缩压的中位数值已被有力地再次确认。再次观察到中位收缩压没有增加的人群，仍然是例外。对这些数据的分析还表明，收缩压随年龄增长的斜率与尿钠、尿钠钾比和报告的饮酒量呈正相关，而尿钾排泄与血压斜率呈负相关。因此，本分析在以下三个方面补充了INTERSALT研究者先前发表的知识和结果：（1）它们将INTERSALT结果与Epstein和Eckoff提出的假设的种群间变异的生物梯度（包括解释变量）联系起来;（2）40 ~ 49岁的中位血压等级与20 ~ 29岁的中位血压等级之间有很强的相关性;（3）因此，他们支持Epstein和Eckoff最初的人口变异概念，将其与血压风险因素联系起来，并呼吁注意20至29岁人群中已经明显存在的大规模人口差异。
Epstein and Eckoff in 1967 devised a scheme to summarize population differences in the rise of mean values of systolic blood pressure by age in accordance with their slopes and levels. For the first time, the validity of this scheme can be examined with data from a single study, INTERSALT. This study included 52 populations in 32 countries. On the basis of these data, collected in an exceptionally well-standardized mode under a common protocol, the diversity of populations in the slopes of age differences in median values of systolic blood pressure has been strongly reconfirmed. Populations with no increase in median systolic blood pressure were again observed and remained exceptional. The analyses of these data also indicate a positive relation between the slope of rising systolic blood pressure with age and urinary sodium, urinary sodium-potassium ratio, and reported alcohol consumption as well as a negative association between urinary potassium excretion and blood pressure slope. The present analyses therefore add to the previous knowledge and results published by the INTERSALT investigators in the following three respects: (1) they relate INTERSALT results to the postulated biological gradient of variation among populations as presented by Epstein and Eckoff, including explanatory variables; (2) they demonstrate strong correlation between ranks of median blood pressure at 40 to 49 years and values at 20 to 29 years; and (3) they therefore support the original Epstein and Eckoff concept of population variation, link this with blood pressure risk factors, and call attention to the large degree of population differences already evident among populations at 20 to 29 years of age.