Differences in dynamic and static functional connectivity between young and elderly healthy adults
Differences in dynamic and static functional connectivity between young and elderly healthy adults
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DOI：
10.1007/s00234-017-1875-2
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发表时间：
2017-08-01
期刊：
影响因子：
2.8
通讯作者：
Shim, Woo Hyun
中科院分区：
文献类型：
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作者：
Park, Ji Eun;Jung, Seung Chai;Shim, Woo Hyun
目的脑连接是高度动态的，但使用静息状态功能磁共振成像(RS-fMRI)的功能连接(FC)研究假设它是静态的。本研究比较了青年健康成人(YH)和老年健康成人(EH)动态功能障碍与静态功能障碍的差异。方法使用12名青年健康成人和31名老年健康成人的rS-fMRI数据，评估了6个功能区(皮质下、听觉[AUD]、感觉运动[SM]、视觉空间[VS]、认知控制[CC]和默认模式网络[DMN])的功能障碍。静态Fc由Fisher‘s z变换相关系数计算。将滑动时间窗相关(窗口大小30 S，步长3 S)应用于动态FC，并计算滑动窗口之间的标准差。结果EH患者皮质下、CC、DMN区静态Fc降低(fdr校正p=0.0013；74个区域)，无区域静态Fc高于YH。EH显示皮质下、CC和DMN区的动态FC增加，而CC和DMN区的动态FC降低(p<；0.01)。结论在EH和YH中，动态FC与静态FC存在差异，主要集中在认知控制和DMN区域。改变的动态Fc在定性和定量上都显示了不同的暂时性脑活动模式，需要作为衰老过程中的成像生物标志物进行研究。
Purpose Brain connectivity is highly dynamic, but functional connectivity (FC) studies using resting-state functional magnetic resonance imaging (rs-fMRI) assume it to be static. This study assessed differences in dynamic FC between young healthy adults (YH) and elderly healthy adults (EH) compared to static FC.Methods Using rs-fMRI data from 12 YH and 31 EH, FC was assessed in six functional regions (subcortical, auditory [AUD], sensorimotor [SM], visuospatial [VS], cognitive control [CC], and default mode network [DMN]). Static FC was calculated as Fisher's z-transformed correlation coefficient. The sliding time window correlation (window size 30 s, step size 3 s) was applied for dynamic FC, and the standard deviation across sliding windows was calculated. Differences in static and dynamic FC between EH and YH were calculated and compared by region.Results EH showed decreased static FC in the subcortical, CC, and DMN regions (FDR corrected p = 0.0013; 74 regions), with no regions showing static FC higher than that in YH. EH showed increased dynamic FC in the subcortical, CC, and DMN regions, whereas decreased dynamic FC in CC and DMN regions (p < 0.01). However, the regions showing differences between EH and YH did not overlap between static and dynamic FC.Conclusion Dynamic FC exhibited differences from static FC in EH and YH, mainly in regions involved in cognitive control and the DMN. Altered dynamic FC demonstrated both qualitatively and quantitatively distinct patterns of transient brain activity and needs to be studied as an imaging biomarker in the aging process.