IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion
IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion
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DOI：
10.4049/jimmunol.171.11.5727
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发表时间：
2003-12-01
影响因子：
4.4
通讯作者：
Lefrançois, L
中科院分区：
文献类型：
--
作者：
D'Souza, WN;Lefrançois, L
主要基于体外数据，IL-2被认为是启动活化T细胞的细胞周期的关键细胞因子。然而，IL-2在体内T细胞应答中的作用仍未得到解决。我们研究了在CD 8 T细胞中缺乏IL-2介导的信号传导是否影响增殖的起始。我们的研究结果最终表明，抗原特异性CD 8 T细胞的初始分裂后引发是IL-2的独立，无论在其中的Ag提出的背景。相反，增殖期的后期是IL-2依赖性的，特别是在非淋巴组织中。因此，活化的CD 8 T细胞最初经历IL-2非依赖性增殖，但达到对IL-2作为生长因子的需求变得突出的关键时刻。
Based primarily on in vitro data, IL-2 is believed to be the key cytokine for initiation of the cell cycle of activated T cells. However, the role of IL-2 remains unresolved for T cell responses in vivo. We examined whether the absence of IL-2-mediated signaling in CD8 T cells affected initiation of proliferation. Our results conclusively demonstrated that initial division of Ag-specific CD8 T cells following priming was IL-2 independent, regardless of the context in which Ag was presented. In contrast, the latter stage of the proliferative phase was IL-2-dependent, particularly in nonlymphoid tissues. Thus, activated CD8 T cells initially undergo IL-2-independent proliferation, but reach a critical juncture where the requirement for IL-2 as a growth factor gains prominence.