Separation-friendly Mitsunobu reactions: A microcosm of recent developments in separation strategies
Separation-friendly Mitsunobu reactions: A microcosm of recent developments in separation strategies
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DOI：
10.1002/chem.200400363
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发表时间：
2004-07-05
影响因子：
4.3
通讯作者：
Curran, DP
中科院分区：
文献类型：
--
作者：
Dandapani, S;Curran, DP
光信反应以其范围和力量而闻名，但因其分离头痛而臭名昭着。通常，通过仔细的色谱法将目标产物从试剂衍生的副产物中诱导出来。聚合物结合的Mitsunobu试剂的新使用仅解决了问题的一半，因为聚合物结合的偶氮二羧酸二乙酯（DEAD）和膦试剂不能同时使用。本文对Mitsunobu反应中产物分离的各种新兴策略进行了分类、比较和对比。由于已经使用了如此多的不同策略，Mitsunobu反应是策略水平分离新领域的缩影。
The Mitsunobu reaction is famous for its scope and power, but infamous for its separation headaches. Typically, the target product is enticed away from the reagent-derived byproducts by careful chromatography. ne use of polymer-bound Mitsunobu reagents solves only half of the problem, because polymer-bound diethyl azodicarboxylate (DEAD) and phosphine reagents cannot be employed simultaneously. This article classifies, compares, and contrasts various emerging strategies for product isolation in Mitsunobu reactions. Because so many different strategies have been used, the Mitsunobu reaction is a microcosm for the new field of strategy level separations.