A Quantitative Study of Transport of Surfactant Boli in a Three-Dimensional Lung Model of Neonates
A Quantitative Study of Transport of Surfactant Boli in a Three-Dimensional Lung Model of Neonates
复制标题
新生儿三维肺模型中表面活性剂Boli转运的定量研究
DOI：
10.1115/1.4055428
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Tavana, Hossein
中科院分区：
文献类型：
--
作者：
Combs, Hannah;Shark, Taylor;Heiss, Jacob;Raessi, Mehdi;Tavana, Hossein
新生儿呼吸窘迫综合征的治疗主要采用肺表面活性物质的气管内给药。治疗的成功取决于滴注的表面活性剂溶液到肺的呼吸区的分布均匀性和递送效率。表面活性剂分布的直接成像和定量递送效率在新生儿中是不可行的。为了解决这一主要限制，我们使用人类肺部的形态测量和几何数据设计了新生儿肺气道树的八代计算模型，并使用增材制造技术制造了它。使用这个模型，我们进行了系统的研究，临床表面活性剂的交付，无论是在一个单一的等分试样或在两个等分试样下的不同方向的气道树在重力空间，以模仿滚动新生儿在其一侧的过程中。我们的研究提供了一种新的肺气道模型和新的见解，肺气道的方向和存在的预先存在的表面活性剂膜上的滴注的表面活性剂溶液如何分布在气道的影响。
Neonatal respiratory distress syndrome is mainly treated with the intratracheal delivery of pulmonary surfactants. The success of the therapy depends on the uniformity of distribution and efficiency of delivery of the instilled surfactant solution to the respiratory zone of the lungs. Direct imaging of the surfactant distribution and quantifying the efficiency of delivery is not feasible in neonates. To address this major limitation, we designed an eight-generation computational model of neonate lung airway tree using morphometric and geometric data of human lungs and fabricated it using additive manufacturing. Using this model, we performed systematic studies of delivery of a clinical surfactant either at a single aliquot or at two aliquots under different orientations of the airway tree in the gravitational space to mimic rolling a neonate on its side during the procedure. Our study offers both a novel lung airway model and new insights into effects of the orientation of the lung airways and presence of a pre-existing surfactant film on how the instilled surfactant solution distributes in airways.