Inflammatory mediators as essential elements in bone remodeling
Inflammatory mediators as essential elements in bone remodeling
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DOI：
10.1007/s00223-002-1049-y
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发表时间：
2003-08-01
影响因子：
4.2
通讯作者：
Goldring, SR
中科院分区：
文献类型：
--
作者：
Goldring, SR
炎症性疾病，如类风湿性关节炎(RA)，可能会对骨骼动态平衡产生深远影响。与机械影响和/或全身内分泌激素启动重塑过程的生理性重塑不同，在RA等疾病中，巨噬细胞系细胞向炎症部位募集巨噬细胞，以及与炎症过程相关的局部破骨细胞因子的作用启动重塑过程。在生理性和病理性重塑中，破骨细胞似乎是导致骨吸收的主要细胞类型。此外，许多相同的细胞因子和介质参与生理性和病理性骨重建。这些观察结果对于制定预防炎症条件下骨丢失的治疗策略具有重要意义。
Inflammatory disorders such as rheumatoid arthritis (RA), may have profound effects on skeletal homeostasis. In contrast to physiologic remodeling in which mechanical influences and/or systemic endocrine hormones initiate the remodeling process, in disorders such as RA the recruitment of macrophage lineage cells to sites of inflammation and the action of local osteoclastogenic cytokines associated with the inflammatory process initiate the remodeling process. In both physiologic and pathologic remodeling, osteoclasts appear to be the principal cell type responsible for the bone resorption. In addition, many of the same cytokines and mediators are involved in physiologic and pathologic bone remodeling. These observations have important implications with respect to the development of therapeutic strategies to prevent bone loss in inflammatory conditions.