Toenails as a biomarker of inorganic arsenic intake from drinking water and foods.
Toenails as a biomarker of inorganic arsenic intake from drinking water and foods.
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脚趾甲作为饮用水和食物中无机砷摄入量的生物标志物。
DOI：
10.1080/15287390600755232
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Nriagu,JeromeO
中科院分区：
文献类型：
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作者：
Slotnick,MelissaJ;Meliker,JaymieR;AvRuskin,GillianA;Ghosh,Debashis;Nriagu,JeromeO
最近，流行病学和环境卫生研究中使用脚趾甲作为评估饮用水中砷暴露的一种手段。虽然文献中报道了趾甲和饮用水砷浓度之间的正相关性，但趾甲砷浓度的变化中有很大一部分仍然无法单独用饮用水浓度来解释。在这里，在家里和工作，食物摄入量和饮用水浓度对趾甲砷浓度的影响进行了调查，使用的数据正在进行的病例对照研究在密歇根州的11个县。440个控制的结果。对数转换的饮用水砷浓度在家里是一个显着的预测（p<0.05）的趾甲砷浓度（R2= 0.32）。以饮用自来水和饮用自来水饮料的砷摄入量（μg/L砷× L/d = μg/d）作为预测变量时，砷>1 μg/L的个体的相关性显著增加（R2= 0.48）。增加海鲜的摄入量和砷的摄入量从水中的工作是独立的，显着相关的脚趾甲砷浓度增加。然而，当添加到摄入量在家里，工作饮用水暴露和食物摄入量的影响不大的整体相关性。这些结果表明，砷暴露于饮用水的消费是一个重要的决定因素，脚趾甲砷浓度，因此，应考虑验证和应用脚趾甲作为砷暴露的生物标志物时。
Toenails were used recently in epidemiological and environmental health studies as a means of assessing exposure to arsenic from drinking water. While positive correlations between toenail and drinking-water arsenic concentrations were reported in the literature, a significant percentage of the variation in toenail arsenic concentration remains unexplained by drinking-water concentration alone. Here, the influence of water consumption at home and work, food intake, and drinking-water concentration on toenail arsenic concentration was investigated using data from a case-control study being conducted in 11 counties of Michigan. The results from 440 controls are presented. Log-transformed drinking-water arsenic concentration at home was a significant predictor (p< .05) of toenail arsenic concentration (R2= .32). When arsenic intake from consumption of tap water and beverages made from tap water (μg/L arsenic × L/d = μg/d) was used as a predictor variable, the correlation was markedly increased for individuals with >1 μg/L arsenic (R2= .48). Increased intake of seafood and intake of arsenic from water at work were independently and significantly associated with increased toenail arsenic concentration. However, when added to intake at home, work drinking-water exposure and food intake had little influence on the overall correlation. These results suggest that arsenic exposure from drinking-water consumption is an important determinant of toenail arsenic concentration, and therefore should be considered when validating and applying toenails as a biomarker of arsenic exposure.