Balloon pulmonary angioplasty improves quality of life in Japanese patients with chronic thromboembolic pulmonary hypertension
Balloon pulmonary angioplasty improves quality of life in Japanese patients with chronic thromboembolic pulmonary hypertension
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DOI：
10.1016/j.jjcc.2020.02.015
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发表时间：
2020-08-01
影响因子：
2.5
通讯作者：
Komuro, Issei
中科院分区：
文献类型：
--
作者：
Minatsuki, Shun;Kodera, Satoshi;Komuro, Issei
背景：慢性血栓栓塞性肺动脉高压(CTEPH)的常规治疗目标是改善血流动力学状态，尤其是平均肺动脉压(MPAP)；然而，一些患者抱怨即使在血流动力学状态完全改善后，由于努力呼吸困难而导致的生活质量(QOL)也受到影响。目前尚不清楚治疗CTEPH是否可以改善患者的生活质量，也不清楚生活质量的定量测量是否与血流动力学状态相关。方法和结果：采用欧洲生活质量五维量表(EQ-5D)对45例CTEPH患者的生活质量进行了测评。在最初测量时，除补充氧气外，没有参与任何治疗的45名患者中，有12名患者的平均生活质量得分为0.673+/-0.251。17例患者治疗前后均有明显改善(生活质量从0.741±0.195增至0.802+/-0.160，p<；0.05；平均动脉压从33.0±-8.4增至23.4+/-4.2 mm Hg，p<；0.05；肺血管阻力从441.4+/-214.2增至268.4+/-85.6dyne/S/cm(5)，p<；0.05)。与mPAP(r=-0.37，p&t；0.05)、肺血管阻力(r=-0.40，p<；0.05)、6min步行距离(r=0.45，p<0.05)呈显著正相关。
Background: The conventional treatment goal for chronic thromboembolic pulmonary hypertension (CTEPH) is improving hemodynamic status, particularly mean pulmonary artery pressure (mPAP); however, some patients complain of impaired quality of life (QOL) caused by dyspnea on effort, even after hemodynamic status has fully improved. It remains unclear whether treatment for CTEPH can improve patients' QOL or whether quantitative measures of QOL correlate with hemodynamic status. This study quantified QOL among Japanese CTEPH patients and investigated whether balloon pulmonary angioplasty (BPA) improved QOL.Methods and results: We calculated the QOL scores of 45 CTEPH patients using the European Quality of Life Five Dimension scale (EQ-5D). The mean QOL score among 12 of those 45 not involved in any therapy except supplemental oxygen at the time of initial measurement was 0.673 +/- 0.251. QOL was measured before and after BPA for 17 patients, and the mean significantly improved (QOL from 0.741 +/- 0.195 to 0.802 +/- 0.160, p < 0.05; mPAP from 33.0 +/- 8.4 to 23.4 +/- 4.2 mmHg, p < 0.05; pulmonary vascular resistance from 441.4 +/- 214.2 to 268.4 +/- 85.6 dyne/s/cm(5), p < 0.05). Moreover, the index significantly correlated with mPAP (r= -0.37, p < 0.05), pulmonary vascular resistance (r= -0.40, p < 0.05), 6-min walking distance (r=0.45, p