Structure-guided stereoselectivity inversion of a short-chain dehydrogenase/reductase towards halogenated acetophenones
Structure-guided stereoselectivity inversion of a short-chain dehydrogenase/reductase towards halogenated acetophenones
复制标题
短链脱氢酶/还原酶对卤代苯乙酮的结构引导立体选择性反转
DOI：
10.1039/c6cc00051g
复制
发表时间：
2016-01-01
影响因子：
4.9
通讯作者：
Yu, Hongwei
中科院分区：
文献类型：
--
作者：
Li, Aipeng;Ye, Lidan;Yu, Hongwei
The structure-guided rational design of an NADH-dependent short-chain dehydrogenase/reductase (SDR) reversed the stereoselectivity towards halogenated acetophenones from Prelog to anti-Prelog. The enzyme-substrate interactions involving an aromatic ring and a halogen atom were proven to play critical roles in determining the stereoselectivity of these ketone reductions besides the steric repulsion.
