Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era?
Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era?
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DOI：
10.1183/13993003.02103-2021
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发表时间：
2022-08-01
影响因子：
24.3
通讯作者：
Corrigan, Chris J.
中科院分区：
文献类型：
--
作者：
Riccardi, Daniela;Ward, Jeremy P. T.;Corrigan, Chris J.
在这篇综述文章中，我们提出了迄今为止的证据支持钙敏感受体（CaSR）作为哮喘的关键，多能性分子触发器的作用，并推测局部治疗哮喘与负变构调节剂的CaSR：calcilytics可能的好处。
In this review article we present the evidence to date supporting the role of the calcium-sensing receptor (CaSR) as a key, pluripotential molecular trigger for asthma and speculate on the likely benefits of topical therapy of asthma with negative allosteric modulators of the CaSR: calcilytics.