Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis.
Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis.
复制标题
Menatetrenone（维生素 K2）和骨质量在治疗绝经后骨质疏松症中的作用。
作者：
J. Iwamoto;T. Takeda;Yoshihiro Sato
Menatetrenone（维生素K2）可降低椎骨骨折的发生率，但对绝经后骨质疏松症妇女的骨密度（BMD）影响不大。尽管梅纳特酮对双磷酸盐增加骨密度缺乏累加效应，但双磷酸盐和梅纳特酮的联合治疗在预防椎骨骨折方面可能比单独使用双磷酸盐更有效。Menatetrenone改善卵巢切除大鼠的骨结构，以及镁缺乏大鼠骨基质体积和骨强度（不增加骨量）方面的骨矿物质/基质比。因此，现有证据支持在骨质疏松症治疗期间，甲烯雌酮对骨质量的影响。
Menatetrenone (vitamin K2) reduces the incidence of vertebral fractures but has only modest effects on bone mineral density (BMD) in postmenopausal women with osteoporosis. Combined treatment with bisphosphonates and menatetrenone may be more effective than treatment with bisphosphonates alone in preventing vertebral fractures, despite the lack of an additive effect of menatetrenone on the BMD increase by bisphosphonates. Menatetrenone improves bone architecture in ovariectomized rats, and the mineral/ matrix ratio of the bone in terms of matrix volume and bone strength (without increasing bone mass) in rats with magnesium deficiency. Thus, available evidence supports an effect of menatetrenone on bone quality during osteoporosis treatment.
女性维生素 K 摄入量与髋部骨折：一项前瞻性研究。
DOI：
10.1093/ajcn/69.1.74
发表时间：
1999
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Feskanich,D;Weber,P;Willett,WC;Rockett,H;Booth,SL;Colditz,GA
通讯作者：
Colditz,GA
膳食维生素 K 摄入量与老年男性和女性的髋部骨折有关，但与骨矿物质密度无关。
DOI：
10.1093/ajcn/71.5.1201
发表时间：
2000
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Booth,SL;Tucker,KL;Chen,H;Hannan,MT;Gagnon,DR;Cupples,LA;Wilson,PW;Ordovas,J;Schaefer,EJ;Dawson-Hughes,B;Kiel,DP
通讯作者：
Kiel,DP