DART - LTQ ORBITRAP as an expedient tool for the identification of synthetic cannabinoids
DART - LTQ ORBITRAP as an expedient tool for the identification of synthetic cannabinoids
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DOI：
10.1016/j.legalmed.2016.03.006
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发表时间：
2016-05-01
期刊：
影响因子：
1.5
通讯作者：
Devinsky, Ferdinand
中科院分区：
文献类型：
--
作者：
Habala, Ladislav;Valentova, Jindra;Devinsky, Ferdinand
合成大麻素作为设计药物构成了一个主要问题，因为它们的数量迅速增加，并且在复杂混合物中识别它们存在困难。 DART（实时直接分析）已成为通过质谱直接快速分析复杂样品的有利工具。在这里，我们报告了结合使用环境压力离子源 DART 和混合离子阱 - LTQ ORBITRAP 质谱仪，对来自各种基质中的查获材料的六种合成大麻素进行了鉴定。该报告还描述了所提供的含有大麻素的草药材料的采样技术，无论是直接作为植物部分还是作为甲醇提取物，及其对分析结果的影响。 LTQ ORBITRAP 仪器提供的高分辨率质谱可以明确指定目标化合物。事实证明，所使用的仪器耦合是识别真实样品中合成大麻素的便捷方法。 (C) 2016 Elsevier Ireland Ltd. 保留所有权利。
Synthetic cannabinoids as designer drugs constitute a major problem due to their rapid increase in number and the difficulties connected with their identification in complex mixtures. DART (Direct Analysis in Real Time) has emerged as an advantageous tool for the direct and rapid analysis of complex samples by mass spectrometry. Here we report on the identification of six synthetic cannabinoids originating from seized material in various matrices, employing the combination of ambient pressure ion source DART and hybrid ion trap - LTQ ORBITRAP mass spectrometer. This report also describes the sampling techniques for the provided herbal material containing the cannabinoids, either directly as plant parts or as an extract in methanol and their influence on the outcome of the analysis. The high resolution mass spectra supplied by the LTQ ORBITRAP instrument allowed for an unambiguous assignment of target compounds. The utilized instrumental coupling proved to be a convenient way for the identification of synthetic cannabinoids in real-world samples. (C) 2016 Elsevier Ireland Ltd. All rights reserved.