Cell-assisted lipotransfer for facial lipoatrophy: Efficacy of clinical use of adipose-derived stem cells
Cell-assisted lipotransfer for facial lipoatrophy: Efficacy of clinical use of adipose-derived stem cells
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DOI：
10.1111/j.1524-4725.2008.34256.x
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发表时间：
2008-09-01
影响因子：
2.4
通讯作者：
Harii, Kiyonori
中科院分区：
文献类型：
--
作者：
Yoshimura, Kotaro;Sato, Katsujiro;Harii, Kiyonori
背景脂肪注射是一种很有前途的治疗方法，但其在重塑面部脂肪萎缩方面的疗效仍有待建立。目的：评估脂肪注射和补充脂肪干细胞/基质细胞（ASCs）到脂肪移植物中的疗效和不良反应。方法：为了克服自体脂肪注射的缺点，我们开发了一种新的策略，称为细胞辅助脂肪移植（CAL）。在CAL中，从一半的抽吸脂肪样品中新鲜分离含有ASC的基质血管部分，并将其附着到另一半的抽吸脂肪样品上，其中脂肪充当支架。这一过程将相对缺乏ASC的抽吸脂肪转化为富含ASC的脂肪。我们进行了常规的脂肪注射（非CAL; n=3）或CAL（n=3）对6例面部脂肪萎缩，由于狼疮深或Parry-Romberg syndrome.RESULTS所有患者的面部轮廓得到改善，但CAL组有一个更好的临床改善评分比非CAL患者，虽然差异没有达到统计学意义（p= 0.11）。脂肪坏死被发现在一个non-CAL例谁采取围手术期口服皮质类固醇。结论我们的研究结果表明，CAL是有效的和安全的，并可能上级传统的脂肪注射面部重塑。
BACKGROUND Lipoinjection is a promising treatment, but its efficacy in recontouring facial lipoatrophy remains to be established.OBJECTIVE The objective was to evaluate the efficacy and adverse effects of lipoinjection and supplementation of adipose-derived stem/stromal cells (ASCs) to adipose grafts.METHODS To overcome drawbacks of autologous lipoinjection, we have developed a novel strategy called cell-assisted lipotransfer (CAL). In CAL, stromal vascular fraction containing ASCs was freshly isolated from half of an aspirated fat sample and attached to the other half of aspirated fat sample with the fat acting as a scaffold. This process converts relatively ASC-poor aspirated fat into ASC-rich fat. We performed conventional lipoinjection (non-CAL; n=3) or CAL (n=3) on six patients with facial lipoatrophy due to lupus profundus or Parry-Romberg syndrome.RESULTS All patients obtained improvement in facial contour, but the CAL group had a better clinical improvement score than did the non-CAL patients, although the difference did not reach statistical significance (p=.11). Adipose necrosis was found in one non-CAL case who took perioperative oral corticosteroids.CONCLUSION Our results suggest that CAL is both effective and safe and potentially superior to conventional lipoinjection for facial recontouring.