Body mass index and the risk of Parkinson disease
Body mass index and the risk of Parkinson disease
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DOI：
10.1212/01.wnl.0000247052.18422.e5
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发表时间：
2006-12-12
期刊：
影响因子：
9.9
通讯作者：
Tuomilehto, J.
中科院分区：
文献类型：
--
作者：
Hu, G.;Jousilahti, P.;Tuomilehto, J.
目的：探讨体重指数（BMI）与帕金森病（PD）发病风险的关系。方法：研究队列包括22，367名芬兰男性和23，439名女性，年龄在25至59岁之间，基线时没有PD病史。估计不同BMI水平的PD事件的风险比（HR）。结果：在平均18.8年的随访期间，272名男性和254名女性发生了PD事件。在调整混杂因素后（年龄、学习年限、收缩压、总胆固醇、教育、休闲时间体力活动、吸烟、饮酒、咖啡和茶的摄入），不同BMI水平下PD的HR（< 23、23 ~ 24.9、25 ~ 26.9、27 ~ 29.9和>= 30 kg/m2）分别为1.00、1.97（95% CI：1.21 - 3.22），1.83（95% CI：1.12 - 2.99），2.34（95% CI：1.45 - 3.78）和2.44（95% CI：1.44至4.15），男性为1.00，1.50（95% CI：0.95 - 2.37），1.65（95% CI：1.05 - 2.59），1.79（95% CI：1.15 - 2.80）和1.77（95% CI：1.12 - 2.78），女性为1.00，1.70（95% CI：1.23 - 2.37）、1.70（95% CI：1.23 - 2.37）、2.02（95% CI：1.46 - 2.79）和2.03（95% CI：1.44 - 2.85）（也根据性别调整）。在两种性别中，BMI与PD风险之间的多变量校正直接相关性在25至49岁和50至59岁的受试者中，从不吸烟者和吸烟者以及65岁之前和之后诊断为PD的参与者中均存在。结论：体重指数与帕金森病的风险相关。这种影响是分级的，与其他风险因素无关。
Objective: To examine the association between body mass index (BMI) and the risk of Parkinson disease (PD). Methods: Study cohorts included 22,367 Finnish men and 23,439 women 25 to 59 years of age without a history of PD at baseline. Hazards ratios (HRs) of incident PD were estimated for different levels of BMI. Results: During a mean follow-up period of 18.8 years, 272 men and 254 women developed incident PD. After adjustment for confounding factors ( age, study years, systolic blood pressure, total cholesterol, education, leisure-time physical activity, smoking, and alcohol, coffee, and tea consumption), the HRs of PD at different levels of BMI (< 23, 23 to 24.9, 25 to 26.9, 27 to 29.9, and >= 30 kg/m(2)) were 1.00, 1.97 (95% CI: 1.21 to 3.22), 1.83 (95% CI: 1.12 to 2.99), 2.34 (95% CI: 1.45 to 3.78), and 2.44 (95% CI: 1.44 to 4.15) in men, and 1.00, 1.50 (95% CI: 0.95 to 2.37), 1.65 (95% CI: 1.05 to 2.59), 1.79 (95% CI: 1.15 to 2.80), and 1.77 (95% CI: 1.12 to 2.78) in women, and 1.00, 1.70 (95% CI: 1.23 to 2.37), 1.70 (95% CI: 1.23 to 2.37), 2.02 (95% CI: 1.46 to 2.79), and 2.03 (95% CI: 1.44 to 2.85) in men and women combined (adjusted also for sex). In both sexes combined, the multivariate-adjusted direct association between BMI and the risk of PD was present both in subjects aged 25 to 49 years and 50 to 59 years, in never smokers and smokers and in participants diagnosed PD before and after 65 years of age. Conclusion: Body mass index is associated with a risk of Parkinson disease. The effect is graded and independent of other risk factors.