Neurovascular dynamics of repeated cortical spreading depolarizations after acute brain injury.
Neurovascular dynamics of repeated cortical spreading depolarizations after acute brain injury.
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DOI：
10.1016/j.celrep.2021.109794
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发表时间：
2021-10-05
期刊：
影响因子：
8.8
通讯作者：
Hillman EMC
中科院分区：
文献类型：
--
作者：
Zhao HT;Tuohy MC;Chow D;Kozberg MG;Kim SH;Shaik MA;Hillman EMC
Cortical spreading depolarizations (CSDs) are increasingly suspected to play an exacerbating role in a range of acute brain injuries, including stroke, possibly through their interactions with cortical blood flow. We use simultaneous wide-field imaging of neural activity and hemodynamics in Thy1-GCaMP6f mice to explore the neurovascular dynamics of CSDs during and following Rose Bengal-mediated photothrombosis. CSDs are observed in all mice as slow-moving waves of GCaMP fluorescence extending far beyond the photothrombotic area. Initial CSDs are accompanied by profound vasoconstriction and leave residual oligemia and ischemia in their wake. Later, CSDs evoke variable responses, from constriction to biphasic to vasodilation. However, CSD-evoked vasoconstriction is found to be more likely during rapid, high-amplitude CSDs in regions with stronger oligemia and ischemia, which, in turn, worsens after each repeated CSD. This feedback loop may explain the variable but potentially devastating effects of CSDs in the context of acute brain injury. Zhao et al. use wide-field optical mapping of neuronal and hemodynamic activity in mice, capturing CSDs immediately following photothrombosis. Initial CSDs are accompanied by strong vasoconstriction, leaving persistent oligemia and ischemia. Region-dependent neurovascular responses to subsequent CSDs demonstrate a potential vicious cycle of CSD-dependent damage in acute brain injury.
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影响因子：
14.5
作者：
Dreier, Jens P.;Woitzik, Johannes;Strong, Anthony J.
通讯作者：
Strong, Anthony J.
影响因子：
2.5
作者：
Gniel, Helen M.;Martin, Rosemary L.
通讯作者：
Martin, Rosemary L.
影响因子：
16.2
作者：
Chen Q;Cichon J;Wang W;Qiu L;Lee SJ;Campbell NR;Destefino N;Goard MJ;Fu Z;Yasuda R;Looger LL;Arenkiel BR;Gan WB;Feng G
通讯作者：
Feng G
DOI：
10.1093/brain/awp102
发表时间：
2009-07
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Dreier JP;Major S;Manning A;Woitzik J;Drenckhahn C;Steinbrink J;Tolias C;Oliveira-Ferreira AI;Fabricius M;Hartings JA;Vajkoczy P;Lauritzen M;Dirnagl U;Bohner G;Strong AJ;COSBID study group
通讯作者：
COSBID study group
影响因子：
4.2
作者：
Dotson, Abby L.;Offner, Halina
通讯作者：
Offner, Halina