The influence of behavioral context on the representation of a perceptual decision in developing oculomotor commands
The influence of behavioral context on the representation of a perceptual decision in developing oculomotor commands
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DOI：
10.1523/jneurosci.23-02-00632.2003
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发表时间：
2003-01-15
影响因子：
5.3
通讯作者：
Shadlen, MN
中科院分区：
文献类型：
--
作者：
Gold, JI;Shadlen, MN
为了对感官刺激做出决定，大脑必须权衡支持或反对不同解释的证据。在本研究中，我们评估了一个假设，即反映感官证据权重的数量在负责指示决策的行为反应的大脑回路中表示。我们训练猴子决定随机点运动的方向，并通过对两个选择目标之一的眼球运动来表明他们的决定。我们通过电微刺激额眼野来中断决策形成，引起引起的眼球运动受到持续的动眼肌活动的影响。在“前扫视”版本的任务中，正确的目标在运动方向上的已知位置，微刺激引起的眼球运动反映了即将发生的前扫视反应和用于选择该反应的运动信息的时间积累。相比之下，在“有颜色的目标”任务中，正确的目标是一种特定的颜色，但在一个不可预测的位置，很少有持续的眼球运动活动是明显的。结果表明，决策的形成和行为反应的形成具有共同的神经组织水平，但只有当决策与特定的、可预测的运动相关联时才如此。
To make decisions about sensory stimuli, the brain must weigh the evidence that supports or opposes the alternative interpretations. In the present study, we evaluated the hypothesis that a quantity reflecting the weight of sensory evidence is represented in brain circuits responsible for the behavioral response used to indicate the decision. We trained monkeys to decide the direction of random-dot motion and to indicate their decision with an eye movement to one of two choice targets. We interrupted decision formation with electrical microstimulation of the frontal eye field, causing an evoked eye movement that is influenced by ongoing oculomotor activity. For the "pro-saccade" version of the task, in which the correct target was at a known location in the direction of motion, the microstimulus-evoked eye movement reflected both the impending pro-saccadic response and the temporal accumulation of motion information used to select that response. In contrast, for the "colored-target" task, in which the correct target was of a particular color but at an unpredictable location, little ongoing oculomotor activity was evident. The results suggest that formation of the decision and formation of the behavioral response share a common level of neural organization, but only when the decision is associated with a specific, predictable movement.