Novel Vertical Cup-to-Disc Classification to Identify Normal Eyes That Maintain Non-Glaucoma Status: A 10-Year Longitudinal Study
Novel Vertical Cup-to-Disc Classification to Identify Normal Eyes That Maintain Non-Glaucoma Status: A 10-Year Longitudinal Study
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DOI：
10.1097/ijg.0000000000002109
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发表时间：
2023-02-01
影响因子：
2
通讯作者：
Kinoshita，Shigeru
中科院分区：
文献类型：
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作者：
Ikeda，Yoko;Mori，Kazuhiko;Kinoshita，Shigeru
目的：本研究的目的是制定一个分类，区分对象保持非青光眼状态10年使用VCDR.Participants和方法：在842名志愿者40岁及以上，421名志愿者参加了第二次眼科检查后10年，他们的第一次检查。每位志愿者在首次青光眼筛查中被诊断为健康正常或青光眼可疑（GS）。前者又分为N1、N2、N3三个等级。具体而言，N1表示（1）VCDR< 0.3;（2）无切迹或神经纤维层缺损;（3）无破坏，N2表示N1的0.3≤ VCDR< 0.6和条件（2）和（3）; N3表示N1的0.3≤ VCDR< 0.6和条件（2），或0.6≤ VCDR< 0.7和条件（2）。青光眼转换率（GTR）进行了评估，在421名志愿者谁返回参加后10 years period.Results：GTR计算为1.3%，在N1和N2，3.9%，在N3和GS的18.2%。结论：在10年的研究期间，N1和N2的GTR低于N3或GS。这种对健康非青光眼受试者的新分类可能有助于识别那些保持非青光眼状态长达10年的受试者，尤其是日本男性。
Purpose:This study aimed to develop a classification for distinguishing subjects maintaining non-glaucoma status for 10 years using the VCDR.Participants and Methods:Among 842 volunteers 40 years and older, 421 volunteers participated in the second ophthalmic examination 10 years after their first examination. Each volunteer was diagnosed either as healthy normal or glaucoma suspect (GS) in the first glaucoma screening examinations. The former was further classified into the 3 grades of N1, N2, and N3. Specifically, N1 represented (1) VCDR< 0.3;(2) no notching or nerve fiber layer defect; and (3) no undermining, N2 indicated 0.3≤ VCDR< 0.6 and conditions (2) and (3) of N1; and N3 represented 0.3≤ VCDR< 0.6 with undermining and condition (2), or 0.6≤ VCDR< 0.7 and condition (2) of N1. Glaucoma transition rates (GTRs) were evaluated in 421 volunteers who returned to participate after a 10-year period.Results:GTRs were calculated as 1.3% in both N1 and N2, 3.9% in N3, and 18.2% in GS. The ratio of volunteers in the same category maintenance rate increased from N1 to N3.Conclusion:GTRs were lower in N1 and N2 than in N3 or GS during the 10-year study period. This novel classification of healthy non-glaucoma subjects may help identify those, especially Japanese males, who maintain a non-glaucoma status for an extended period of 10 years.