Conditioned enhancement of firing rates and synchrony of hippocampal neurons and firing rates of motor cortical neurons in rats.
Conditioned enhancement of firing rates and synchrony of hippocampal neurons and firing rates of motor cortical neurons in rats.
复制标题
条件性增强大鼠海马神经元的放电率和同步性以及运动皮质神经元的放电率。
DOI：
10.1111/ejn.12070
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发表时间：
2013
影响因子：
3.4
通讯作者：
S.
中科院分区：
文献类型：
--
作者：
Sakurai;Y. and Takahashi;S.
这项研究的目的是检查神经元群的潜在能力，以提高他们的活动条件没有行为。我们采用了一种神经元操作性条件反射的方法，在没有行为的情况下，运动皮层和海马中邻近神经元的放电率和同步的增加得到了奖励。大鼠被训练参与一个自由操作任务，其中在第1阶段奖励戳鼻子行为，在第2和第3阶段分别奖励超过预设标准的放电率和同步性。运动皮层和海马神经元组的放电率在第2阶段迅速增加，与第1阶段的戳鼻子行为相似。在第3阶段，将奖励的偶然性置于放电同步上导致只有海马神经元的放电同步选择性增强。对照实验表明，神经元放电的增强与迷信行为的增加或奖赏传递引起的兴奋无关。对各组单个神经元和神经元对的放电速率和同步性的分析表明，各组中部分神经元和神经元对的放电速率和同步性均有所增加。未用于条件反射的相邻电极记录的任何神经元和神经元对均未观察到增强。这些结果表明，神经元操作性条件反射只增强了小范围限制区域内部分神经元的放电速率和同步。本研究结果将为神经康复和神经修复的进一步研究做出贡献。
The aim of this study was to examine the potential ability of neuronal groups to enhance their activities by conditioning without behaviors. We employed a method of neuronal operant conditioning in which increments in the firing rates and synchrony of closely neighboring neurons in the motor cortex and hippocampus were rewarded in the absence of behaviors. Rats were trained to engage in a free‐operant task in which nose‐poke behaviors were rewarded in session 1, and firing rates and synchrony above preset criteria were rewarded in sessions 2 and 3, respectively. The firing rates of motor cortical and hippocampal neuron groups were found to increase rapidly in session 2 similarly to the nose‐poke behavior in session 1. Placing contingency of reward on firing synchrony resulted in selective enhancement of firing synchrony of only hippocampal neurons in session 3. Control experiments revealed that the enhancement of neuronal firing was not attributable to increments of superstitious behaviors or excitation caused by reward delivery. Analysis of the firing rates and synchrony of individual neurons and neuron pairs in each group revealed that the firing rates and synchrony of some but not all neurons and neuron pairs increased in each group. No enhancement was observed in any neurons and neuron pairs recorded by neighboring electrodes not used for conditioning. These results suggest that neuronal operant conditioning enhances the firing rates and synchrony of only some neurons in small restricted areas. The present findings are expected to contribute to further research into neurorehabilitation and neuroprosthesis.