CROSS-REGULATORY INTERACTIONS AMONG THE GAP GENES OF DROSOPHILA
CROSS-REGULATORY INTERACTIONS AMONG THE GAP GENES OF DROSOPHILA
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DOI：
10.1038/324668a0
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发表时间：
1986-12-18
期刊：
影响因子：
64.8
通讯作者：
LEHMANN, R
中科院分区：
文献类型：
--
作者：
JACKLE, H;TAUTZ, D;LEHMANN, R
果蝇胚胎的分割涉及几类合子基因的表达，以响应母体起源的位置信息1。GAP基因的合子表达被认为是将胚胎细分为几个相邻片段单位所必需的；配对规则基因建立两个片段的重复单位长度，片段极性基因指定单个片段的一部分2-5。这三类片段基因提供的位置信息被解释为利用同源基因6-10建立片段同一性。几个片段和同源基因的分子探针揭示了基因在幼胚11-18中表达的时空模式。这些基因在突变胚胎中表达模式的变化为同源基因和配对基因19-23之间的相互作用网络提供了证据，该网络本身取决于GAP基因24-27的活性。我们在这里表明，GAP基因表达的空间限制取决于GAP基因之间的双边相互作用。
Segmentation of theDrosophilaembryo involves expression of several classes of zygotic genes in response to positional information of maternal origin1. Zygotic expression of the gap genes is thought to be required for the subdivision of the embryo into several units of adjacent segments; pair-rule genes establish a repeat unit length of two segments and segment polarity genes specify parts of the single segment2–5. The positional information provided by the three classes of segmentation genes is interpreted for the establishment of segment identity using the homoeotic genes6–10. Molecular probes for several segmentation and homoeotic genes reveal a temporal and spatial pattern of gene expression in the young embryo11–18. Changes in the pattern of expression of these genes in mutant embryos provide evidence for a network of interactions among homoeotic and pair-rule genes19–23that itself depends on the activity of gap genes24–27. We show here that the spatial limit of gap gene expression depends on bilateral interactions among gap genes.