Serial intravascular ultrasound assessment of changes in coronary atherosclerotic plaque dimensions and composition: an update
Serial intravascular ultrasound assessment of changes in coronary atherosclerotic plaque dimensions and composition: an update
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DOI：
10.1093/ejechocard/jer017
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发表时间：
2011-04-01
影响因子：
--
通讯作者：
von Birgelen, Clemens
中科院分区：
文献类型：
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作者：
Hartmann, Marc;Huisman, Jennifer;von Birgelen, Clemens
本文综述了在最近的观察性研究和随机试验中使用连续血管内超声（IVUS）检查冠状动脉粥样硬化，这些研究揭示了降胆固醇和调脂治疗的效果，并提供了对斑块进展和消退的新见解。我们讨论了斑块进展-消退作为补充成像终点和心血管事件风险的潜在替代标志物的价值。此外，在一系列评估冠状动脉斑块组成和斑块易损性的射频分析的进展进行了审查。最后，我们报告了最近的系列IVUS试验中真实血管重塑的评价，并讨论了冠状动脉粥样硬化系列侵入性成像的未来前景。
This manuscript reviews the use of serial intravascular ultrasound (IVUS) examination of coronary atherosclerosis in recent observational studies and randomized trials that revealed the effects of cholesterol-lowering and lipid-modifying therapies and offered novel insight into plaque progression and regression. We discuss the value of plaque progression-regression as complementary imaging endpoint and potential surrogate marker of cardiovascular event risk. In addition, the progress in serial assessment of coronary plaque composition and plaque vulnerability by radiofrequency-based analyses is reviewed. Finally, we report on the evaluation of true vessel remodelling in recent serial IVUS trials and discuss the future perspective of serial invasive imaging of coronary atherosclerosis.