Associations between education and brain structure at age 73 years, adjusted for age 11 IQ
Associations between education and brain structure at age 73 years, adjusted for age 11 IQ
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DOI：
10.1212/wnl.0000000000003247
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发表时间：
2016-10-25
期刊：
影响因子：
9.9
通讯作者：
Deary, Ian J.
中科院分区：
文献类型：
--
作者：
Cox, Simon R.;Dickie, David Alexander;Deary, Ian J.
目的：为了研究教育与老年人大脑结构之间的联系如何通过调整11岁时测量的智商来影响。方法：我们分析了1936年出生的617名社区居民在73岁时接受全日制教育的年限和MRI脑扫描的测量结果。除了平均和顶点方向的皮质厚度，我们测量了总脑萎缩和白色物质束分数各向异性。大脑结构和教育之间的关联进行了测试，共变的性别和血管健康;第二个模型也共变的年龄11 iQ.Results：教育和平均皮质厚度（β = 0.124，p = 0.004）之间的显着关系减少了23%，当年龄11智商（β = 0.096，p = 0.041）。较长的教育和更大的顶点皮层厚度之间的初始关联在双侧颞叶，内侧额叶，顶叶，感觉和运动皮层显着。考虑到儿童期智力，显著顶点的数量减少了90%以上;只有双侧前颞叶联合仍然存在。无论是教育，也没有年龄11智商显着相关的总脑萎缩或tract-averaged分数anisotropic.Conclusions：年的教育和大脑结构之间的关联约60年后被限制在这个样本中的皮质厚度，然而，以前报道的长期教育和较厚的皮质之间的关联可能是高估的幅度和分布。这一发现对理解并可能改善生命过程中的大脑健康具有重要意义。
Objective: To investigate how associations between education and brain structure in older age were affected by adjusting for IQ measured at age 11.Methods: We analyzed years of full-time education and measures from an MRI brain scan at age 73 in 617 community-dwelling adults born in 1936. In addition to average and vertex-wise cortical thickness, we measured total brain atrophy and white matter tract fractional anisotropy. Associations between brain structure and education were tested, covarying for sex and vascular health; a second model also covaried for age 11 IQ.Results: The significant relationship between education and average cortical thickness (beta = 0.124, p = 0.004) was reduced by 23% when age 11 IQ was included (beta = 0.096, p = 0.041). Initial associations between longer education and greater vertex-wise cortical thickness were significant in bilateral temporal, medial-frontal, parietal, sensory, and motor cortices. Accounting for childhood intelligence reduced the number of significant vertices by >90%; only bilateral anterior temporal associations remained. Neither education nor age 11 IQ was significantly associated with total brain atrophy or tract-averaged fractional anisotropy.Conclusions: The association between years of education and brain structure approximate to 60 years later was restricted to cortical thickness in this sample; however, the previously reported associations between longer education and a thicker cortex are likely to be overestimates in terms of both magnitude and distribution. This finding has implications for understanding, and possibly ameliorating, life-course brain health.