Cytomegalovirus infection in the acquired immunodeficiency syndrome. Clinical and autopsy findings.
Cytomegalovirus infection in the acquired immunodeficiency syndrome. Clinical and autopsy findings.
复制标题
获得性免疫缺陷综合征中的巨细胞病毒感染。
DOI：
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发表时间：
1988
影响因子：
4.6
通讯作者：
D. Shibata
中科院分区：
文献类型：
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作者：
E. Klatt;D. Shibata
本文综述了获得性免疫缺陷综合征（AIDS）患者巨细胞病毒（CMV）感染的临床和尸检结果。在164例患者中，81例在尸检时有CMV感染的证据，但仅17例发生CMV导致的器官衰竭。艾滋病合并巨细胞病毒和不合并巨细胞病毒患者之间的人口统计学差异很小。巨细胞病毒从来不是任何患者艾滋病的唯一诊断标准，但总是伴有至少一种其他机会性感染或肿瘤。总的临床病程在两组之间没有显著差异，但CMV患者的最终住院时间要长得多。CMV治疗延长了某些病例的临床病程，但不能消除感染或预防CMV死亡。尸检时，最常见的受累部位为肾上腺（75%）、肺（58%）、胃肠道（30%）、中枢神经系统（20%）和眼（10%）。大多数患者（62%）有多个部位受累。大体病理学发现是常见的，但往往微妙。伴随CMV夹杂物的显微镜变化是可变的，通常程度有限。
The clinical and autopsy findings of cytomegalovirus (CMV) infection in patients with the acquired immunodeficiency syndrome (AIDS) are reviewed. Of 164 patients, 81 had evidence of CMV infection at autopsy, but organ failure leading to patient demise from CMV occurred in only 17. Demographic differences between patients with AIDS with and without CMV were minimal. Cytomegalovirus was never the sole diagnostic criterion for AIDS in any patient but was always accompanied by at least one other opportunistic infection or neoplasm. The total clinical course did not significantly differ between the two groups, but the length of final hospitalization of patients with CMV was much longer. Therapy for CMV prolonged the clinical course in some cases but did not eliminate the infection or prevent death from CMV. At autopsy the most common sites of involvement were adrenal (75%), pulmonary (58%), gastrointestinal (30%), central nervous system (20%), and ocular (10%). Most patients (62%) had multiple sites of involvement. Gross pathologic findings were frequent but often subtle. Microscopic changes accompanying CMV inclusions were variable and usually limited in extent.