The coexistence of TrkA with putative transmitter agents and calcium-binding proteins in the vagal and glossopharyngeal sensory neurons of the adult rat.
The coexistence of TrkA with putative transmitter agents and calcium-binding proteins in the vagal and glossopharyngeal sensory neurons of the adult rat.
复制标题
TrkA 与成年大鼠迷走神经和舌咽感觉神经元中假定的递质和钙结合蛋白的共存。
DOI：
10.1016/s0006-8993(99)02016-8
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发表时间：
1999
期刊：
影响因子：
2.9
通讯作者：
Helke,CJ
中科院分区：
文献类型：
--
作者：
Ichikawa,H;Helke,CJ
神经营养因子受体，TrkA，在神经化学鉴定迷走神经和舌咽感觉神经元的成年大鼠的存在进行了检查。TrkA与降钙素基因相关肽（CGRP）、小清蛋白或钙结合蛋白D-28 k共定位于结状神经节、岩神经节和/或颈静脉神经节的神经元。在颈静脉和岩神经节中约有一半的TrkA-ir神经元含有CGRP-ir，而在结状神经节中仅有少数TrkA-ir神经元含有CGRP-ir。岩神经节或颈静脉神经节中很少或没有TrkA-ir神经元也被标记为钙结合蛋白。这些数据表明，不同的共定位的TrkA与特定的神经化学物质在迷走神经和舌咽感觉神经元，并建议神经生长因子（NGF），神经营养因子配体的TrkA，发挥作用的功能，特定的神经化学定义的亚群的成熟迷走神经和舌咽感觉神经元。
The presence of the neurotrophin receptor, TrkA, in neurochemically identified vagal and glossopharyngeal sensory neurons of the adult rat was examined. TrkA was colocalized with calcitonin gene-related peptide (CGRP), parvalbumin, or calbindin D-28k in neurons of the nodose, petrosal and/or jugular ganglia. In contrast, no TrkA-immunoreactive (ir) neurons in these ganglia colocalized tyrosine hydroxylase-ir. About one-half of the TrkA-ir neurons in the jugular and petrosal ganglia contained CGRP-ir, whereas only a few of the numerous TrkA-ir neurons in the nodose ganglion contained CGRP-ir. Although 43% of the TrkA-ir neurons in the nodose ganglion contained calbindin D-28k-ir, few or no TrkA-ir neurons in the petrosal or jugular ganglia were also labeled for either calcium-binding protein. These data show distinct colocalizations of TrkA with specific neurochemicals in vagal and glossopharyngeal sensory neurons, and suggest that nerve growth factor (NGF), the neurotrophin ligand for TrkA, plays a role in functions of specific neurochemically defined subpopulations of mature vagal and glossopharyngeal sensory neurons.