The Sjögren's Working Group: The 2023 OMERACT meeting and provisional domain generation.
The Sjögren's Working Group: The 2023 OMERACT meeting and provisional domain generation.
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Sjögren 工作组：2023 年 OMERACT 会议和临时域名生成。
DOI：
10.1016/j.semarthrit.2024.152378
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发表时间：
2024
影响因子：
5
通讯作者：
Fisher,Benjam
中科院分区：
文献类型：
--
作者：
Gordon,RachaelA;Nguyen,Yann;Foulquier,Nathan;Beydon,Maxime;Gheita,TamerA;Hajji,Raouf;Sahbudin,Ilfita;Hoi,Alberta;Ng,Wan-Fai;Mendonça,JoseAlexandre;Wallace,DanielJ;Shea,Beverley;Bruyn,GeorgeAw;Goodman,SusanM;Fisher,Benjam
干燥病（SjD）是一种全身性自身免疫性外分泌病，主要特征是干燥、疼痛和疲劳。SjD可以影响任何器官系统，并在个体中表现出各种各样的表现。这种异质性是开发有效的疾病修饰治疗的主要障碍之一。定义包括特定临床特征和患者经历的核心疾病领域是定义这种复杂疾病的关键第一步。OMERACT SjD工作组于2023年举行了第一次国际合作混合会议，应用OMERACT 2.2过滤器识别核心域。我们完成了第一个目标，即在2023年5月举行的特别兴趣小组上提交的范围界定文献综述。在范围界定审查中确定的领域的基础上，我们独特地部署了多学科专家作为我们合作团队的一部分，以生成一个临时的领域列表，该列表可以捕获SjD异质性。
Sjögren's disease (SjD) is a systemic autoimmune exocrinopathy with key features of dryness, pain, and fatigue. SjD can affect any organ system with a variety of presentations across individuals. This heterogeneity is one of the major barriers for developing effective disease modifying treatments. Defining core disease domains comprising both specific clinical features and incorporating the patient experience is a critical first step to define this complex disease. The OMERACT SjD Working Group held its first international collaborative hybrid meeting in 2023, applying the OMERACT 2.2 filter toward identification of core domains. We accomplished our first goal, a scoping literature review that was presented at the Special Interest Group held in May 2023. Building on the domains identified in the scoping review, we uniquely deployed multidisciplinary experts as part of our collaborative team to generate a provisional domain list that captures SjD heterogeneity.