Levetiracetam reduces spike-wave density and duration during continuous EEG monitoring in patients with idiopathic generalized epilepsy.
Levetiracetam reduces spike-wave density and duration during continuous EEG monitoring in patients with idiopathic generalized epilepsy.
复制标题
左乙拉西坦可降低特发性全身性癫痫患者连续脑电图监测期间的棘波密度和持续时间。
DOI：
10.1111/j.0013-9580.2004.39503.x
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发表时间：
2004
期刊：
影响因子：
5.6
通讯作者：
Gilliam,FrankG
中科院分区：
文献类型：
--
作者：
Gallagher,MartinJ;Eisenman,LawrenceN;Brown,KellyM;Erbayat-Altay,Ebru;Hecimovic,Hrvoje;Fessler,AJames;Attarian,HrayrP;Gilliam,FrankG
左乙拉西坦（LEV）可降低定位相关性癫痫患者癫痫发作(1)和间期癫痫样复合体(2)的发生率。本文定量分析了LEV对10例特发性广泛性癫痫（IGE）患者间期峰波复合物（SWCs）的发生率（峰波密度，SWD）和持续时间的影响。作为诊断评估的一部分，这些患者接受了连续的视频/脑电图监测，并被确定为IGE[通过病史、间歇期和间歇期脑电图结果以及正常的磁共振成像（MRI）诊断]，并在研究期间开始LEV。由于SWD的发生率随时间和睡眠状态的变化而变化，连续脑电图监测的长时间采样允许对SWD和持续时间进行常规脑电图无法进行的统计分析。患者1-3没有完整的脑电图记录。根据详细的视频/脑电图监测报告和保存的脑电图样本确定受试者对LEV的反应。患者1和3在LEV前有频繁的SWCs， LEV后无SWCs。患者2无反应。患者4-10有完整的脑电图记录。每个SWC被视觉识别。SWD定义为每0.2 h时间段内SWC的数量除以0.2。
Levetiracetam (LEV) reduces the incidence of seizures (1) and interictal epileptiform complexes (2) in patients with localization-related epilepsy. Here we report quantitative analyses of the effect of LEV on the incidence (spike–wave density, SWD) and duration of interictal spike–wave complexes (SWCs) in 10 patients with idiopathic generalized epilepsy (IGE). These patients underwent continuous video/EEG monitoring as part of their diagnostic evaluation, were determined to have IGE [diagnosed by history, interictal and ictal EEG findings, and normal magnetic resonance imaging (MRI)], and initiated LEV during the study. Because SWC incidence varies with time and sleep state, the long sampling by continuous EEG monitoring allowed statistical analyses of SWD and duration that could not be made with routine EEGs.Entire EEG records were not available for patients 1–3. Their responses to LEV were determined from the detailed video/EEG monitoring report and saved EEG samples. Patients 1 and 3 had frequent SWCs before LEV and no SWCs after LEV. Patient 2 had no response. Complete EEG records were available for patients 4–10. Each SWC was identified visually. The SWD was defined as the number of SWC in each 0.2-h time period divided by 0.2.