Ductular Reaction in Liver Diseases: Pathological Mechanisms and Translational Significances.
Ductular Reaction in Liver Diseases: Pathological Mechanisms and Translational Significances.
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DOI：
10.1002/hep.30150
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Alpini G
中科院分区：
文献类型：
--
作者：
Sato K;Marzioni M;Meng F;Francis H;Glaser S;Alpini G
胆管反应（DR）是指肝损伤后反应性胆管的增生。DR在病理学上被认为是胆管增生，通常在胆道疾病中观察到。它也可以在各种肝脏疾病中发现，包括非酒精性脂肪肝。DR与肝纤维化和肝损害有关，DR的程度与患者死亡率平行。DR与肝细胞的转分化有关，在肝再生中可能起重要作用，因此引起了科学界的兴趣。DR过程中活性细胞的来源可以是胆管细胞、肝细胞或肝祖细胞，相关信号传导途径可能因研究中使用的特定肝损伤或动物模型而异。虽然需要进一步的研究来阐明详细的机制和在肝脏疾病中的功能作用，但DR可以成为抑制肝纤维化和促进肝再生的治疗靶点。本文综述了以往在患者和动物模型中发现的DR研究以及目前了解的DR机制。
Ductular reaction (DR) is characterized by the proliferation of reactive bile ducts induced by liver injuries. DR is pathologically recognized as bile duct hyperplasia and is commonly observed in biliary disorders. It can also be identified in various liver disorders including non-alcoholic fatty liver disease. DR is associated with liver fibrosis and damage, and the extent of DR parallels to patient mortality. DR raises scientific interests because it is associated with transdifferentiation of liver cells and may play an important role in hepatic regeneration. The origin of active cells during DR can be cholangiocytes, hepatocytes, or hepatic progenitor cells, and associated signaling pathways could differ depending on the specific liver injury or animal models used in the study. Although further studies are needed to elucidate detailed mechanisms and the functional roles in liver diseases, DR can be a therapeutic target to inhibit liver fibrosis and to promote liver regeneration. This review summarizes previous studies of DR identified in patients and animal models as well as currently understood mechanisms of DR.
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影响因子：
64.8
作者：
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DOI：
10.1038/labinvest.2009.6
发表时间：
2009-04
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
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影响因子：
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作者：
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