Tetrahymena Comparative Genomics Database (TCGD): a community resource for Tetrahymena
Tetrahymena Comparative Genomics Database (TCGD): a community resource for Tetrahymena
复制标题
四膜虫比较基因组数据库 (TCGD)：四膜虫社区资源
DOI：
10.1093/database/baz029
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发表时间：
2019-02-27
影响因子：
5.8
通讯作者：
Xiong, Jie
中科院分区：
文献类型：
--
作者：
Yang, Wentao;Jiang, Chuanqi;Xiong, Jie
摘要纤毛虫是一个庞大而多样的单细胞生物类群，其特征是在一个细胞内具有两种不同的细胞核：微核（MIC）和大核（MAC）。虽然已经对不同类群的几种纤毛虫的基因组进行了测序，但还没有一个纤毛虫属内多个物种的比较基因组学数据。本文收集了四膜虫属10个物种的基因组信息和比较基因组学分析结果，包括已测序的模式生物嗜热四膜虫和9个新测序物种，构建了一个属级比较分析平台--四膜虫比较基因组学数据库（TCGD）。基因组序列，转录组数据，基因模型，功能注释，直系同源群和共线性地图内置到这个数据库和用户友好的界面，开发了搜索，可视化和分析这些数据。总之，TCGD（http：ciliate.ihb.ac.cn）将是纤毛虫研究社区的重要和有用的资源。
Abstract Ciliates are a large and diverse group of unicellular organisms characterized by having the following two distinct type of nuclei within a single cell: micronucleus (MIC) and macronucleus (MAC). Although the genomes of several ciliates in different groups have been sequenced, comparative genomics data for multiple species within a ciliate genus are not yet available. Here we collected the genome information and comparative genomics analysis results for 10 species in the Tetrahymena genus, including the previously sequenced model organism Tetrahymena thermophila and 9 newly sequenced species, and constructed a genus-level comparative analysis platform, the Tetrahymena Comparative Genomics Database (TCGD). Genome sequences, transcriptomic data, gene models, functional annotation, ortholog groups and synteny maps were built into this database and a user-friendly interface was developed for searching, visualizing and analyzing these data. In summary, the TCGD (http://ciliate.ihb.ac.cn) will be an important and useful resource for the ciliate research community.