Mechanisms of renal vasodilation after protein feeding: role of the renin-angiotensin system.
Mechanisms of renal vasodilation after protein feeding: role of the renin-angiotensin system.
复制标题
蛋白质喂养后肾血管舒张的机制：肾素-血管紧张素系统的作用。
DOI：
10.1152/ajpregu.1993.264.3.r601
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Woods,LL
中科院分区：
文献类型：
--
作者：
Woods,LL
这些研究旨在确定急性蛋白质喂养时肾脏血流动力学反应中肾素-血管紧张素系统（RAS）的重要性。在慢性仪器清醒的狗在正常的（80 meq/天）钠摄入量，10 g/kg的生牛肉引起肾小球滤过率（GFR）从68 +/- 6 ml/min增加到86 +/- 6 ml/min，有效肾血浆流量（ERPF）从211 +/- 14 ml/min增加到263 +/- 15 ml/min。- 0.14 ng ANG I.ml-1 x h-1，并且没有显著变化。当在输注卡托普利期间重复该方案时，GFR从67 +/- 11增加到97 +/- 10 ml/min，ERPF从264 +/- 74增加到392 +/- 82 ml/min。然后将狗置于低盐饮食（约7 meq/天）以生理激活RAS。在钠限制的狗中，GFR从71 +/- 7增加到104 +/- 10 ml/min，ERPF从226 +/- 15增加到299 +/- 21 ml/min。PRA为3.1 +/- 1.0 ng ANG I.ml-1 x h-1，无变化。因此，无论是阻断RAS与卡托普利或激活RAS的盐限制减少肾血流动力学反应的肉食。这些数据表明，RAS是相对不重要的肾脏血液动力学反应，急性蛋白质喂养。
These studies were designed to determine the importance of the renin-angiotensin system (RAS) in the renal hemodynamic response to acute protein feeding. In chronically instrumented conscious dogs on a normal (80 meq/day) sodium intake, a 10 g/kg meal of raw beef caused glomerular filtration rate (GFR) to increase from 68 +/- 6 to 86 +/- 6 ml/min and effective renal plasma flow (ERPF) to increase from 211 +/- 14 to 263 +/- 15 ml/min. Plasma renin activity (PRA) was 0.44 +/- 0.14 ng ANG I.ml-1 x h-1 and did not change significantly. When the protocol was repeated during infusion of captopril, GFR increased from 67 +/- 11 to 97 +/- 10 ml/min, and ERPF rose from 264 +/- 74 to 392 +/- 82 ml/min after the meat meal. The dogs were then placed on a low-salt diet (approximately 7 meq/day) to physiologically activate the RAS. In sodium-restricted dogs, GFR increased from 71 +/- 7 to 104 +/- 10 ml/min and ERPF increased from 226 +/- 15 to 299 +/- 21 ml/min after the meat meal. PRA was 3.1 +/- 1.0 ng ANG I.ml-1 x h-1 and did not change. Thus neither blockade of the RAS with captopril nor activation of the RAS by salt restriction reduced the renal hemodynamic response to a meat meal. These data indicate that the RAS is relatively unimportant in the renal hemodynamic response to acute protein feeding.