CENTRAL NERVOUS SYSTEM IN MOTOR NEURONE DISEASE
CENTRAL NERVOUS SYSTEM IN MOTOR NEURONE DISEASE
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DOI：
10.1136/jnnp.33.3.338
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发表时间：
1970-01-01
影响因子：
11
通讯作者：
HUGHES, JT
中科院分区：
文献类型：
--
作者：
BROWNELL, B;OPPENHEIMER, DR;HUGHES, JT
本文描述并讨论了45例原发性下运动神经元变性的尸检病例。其中，36例被认为是运动神经元疾病的“典型”病例，其中8例未显示上运动神经元病变。讨论了九个“非典型”病例与其余病例的关系。结论是，运动神经元疾病在多系统萎缩的广谱中构成一个不明确的波段。作者没有发现任何证据表明运动神经元疾病与血管或恶性疾病之间存在因果关系。他们指出了与人类和其他动物的各种亚急性脑脊髓病的暗含类比。
Forty-five necropsied cases with primary degeneration of lower motor neurones are described and discussed. Of these, 36 are considered to be `typical' cases of motor neurone disease, eight of which showed no upper motor neurone lesions. The relation of the nine `atypical' cases to the remainder is discussed. It is concluded that motor neurone disease constitutes an ill-defined band in a broad spectrum of multiple system atrophies. The authors have found no evidence suggesting a causal relation between motor neurone disease and either vascular or malignant diseases. They point out suggestive analogies with various subacute encephalomyelopathies in man and other animals.