Diffusion tensor imaging findings in first-episode and chronic schizophrenia patients
Diffusion tensor imaging findings in first-episode and chronic schizophrenia patients
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DOI：
10.1176/appi.ajp.2008.07101640
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发表时间：
2008-08-01
影响因子：
17.7
通讯作者：
Davis, Kenneth L.
中科院分区：
文献类型：
--
作者：
Friedman, Joseph I.;Tang, Cheuk;Davis, Kenneth L.
目的：对不同研究中评估的首发精神分裂症患者和慢性精神分裂症患者的弥散张量成像(DTI)数据进行比较，发现慢性精神分裂症患者的分数各向异性降低在首发精神分裂症患者中较少。然而，这种跨研究产生的成像数据的比较容易受到许多混杂因素的影响，这可能会限制对任何差异的解释。为了解决这些问题并确定慢性精神分裂症患者发病时是否存在DTI异常，作者对迄今报道的最大的首发精神分裂症患者队列进行了DTI调查，并与一组慢性精神分裂症患者和健康人进行比较。方法：比较40例首发精神分裂症患者和39名年龄和性别匹配的健康对照组以及40名年龄和性别匹配的健康对照组的弥散张量成像产生的分数各向异性数据。结果：在大多数区域，慢性精神分裂症患者表现出显著或趋势水平较低的分数各向异性，而首发精神分裂症患者仅在下纵束表现出趋势水平较低的分数各向异性。结论：本研究报告的横断面数据显示，精神分裂症患者发病时脑白质改变较少，且进展较慢。更明确的结论将需要对首发精神分裂症患者进行后续成像。
Objective: Comparisons of diffusion tensor imaging (DTI) data between first-episode and chronic schizophrenia patients assessed in different studies have led to the suggestion that the decreased fractional anisotropy observed in chronic schizophrenia patients is less pronounced in first-episode patients. However, such comparisons of imaging data generated across studies are susceptible to numerous confounders, which may limit the interpretation of any differences. In order to address these issues and determine whether the DTI abnormalities of chronic schizophrenia are present at illness onset, the authors conducted a DTI investigation of the largest cohort of first-episode schizophrenia patients yet reported in conjunction with a group of chronic schizophrenia patients and healthy subjects for comparison.Method: Fractional anisotropy data generated by diffusion tensor imaging with a 3-T Siemens Allegra head-dedicated MRI system were compared between 40 first-episode schizophrenia patients and 39 age- and gender-matched healthy comparison subjects and between 40 chronic schizophrenia patients and 40 age- and gender-matched healthy comparison subjects. The following regions of interest were assessed: forceps minor (bilaterally), forceps major (bilaterally), inferior longitudinal fasciculus (bilaterally), and the genu and splenium of the corpus callosum.Results: In most regions, chronic schizophrenia patients showed significant or trend-level lower fractional anisotropy than healthy comparison subjects, whereas the first-episode schizophrenia patients showed only trend-level lower fractional anisotropy in the inferior longitudinal fasciculus.Conclusions: The cross-sectional data reported here suggest less widespread changes in white matter at illness onset in schizophrenia which progress in more chronic states. More definitive conclusions will require follow-up imaging of first-episode schizophrenia patients.