Individual variations in the spatial profile of human macular pigment
Individual variations in the spatial profile of human macular pigment
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DOI：
10.1364/josaa.14.001187
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发表时间：
1997-06-01
影响因子：
1.9
通讯作者：
Snodderly, DM
中科院分区：
文献类型：
--
作者：
Hammond, BR;Wooten, BR;Snodderly, DM
测量了32名受试者黄斑色素(MP)密度空间分布的个体差异。在波长为460 nm、12弧度的刺激下，MP的峰密度平均为0.58，标准差(SD)=0.26，范围为0.175~1.39。为了评估MP分布的对称性，测量了水平和垂直子午线上+/-1度偏心的MP密度。这四个地点的密度变化不超过16%，显示出基本对称的分布。基于测量位置之间的线性内插，MP在最大密度的一半处的空间分布宽度平均为1.03狗，SD=0.38，范围为0.25~1.9°。不同受试者MP密度的平均空间分布均符合指数函数和高斯函数。与高斯函数相比，偏心指数衰减可以解释更多的数据差异。假设有偏心的指数衰减，一旦测量了视网膜中央的MP密度(记为A)，则可以用标准化方程(MP=A x 10(-0.42x))预测更偏心位置的MP密度(X，deg)。对于个别情况，与指数函数的微小偏差表明40%的受试者存在较小的侧翼峰值或肩部。我们还检查了四个受试者在4-14个月的时间跨度上的MP分布的时间稳定性，以及10个受试者在1-16年的时间跨度上的单一空间位置的时间稳定性。这些纵向数据表明，如果饮食模式稳定，受试者之间的MP密度差异随着时间的推移而保持不变。(C)1997年美国光学学会。
Individual variations in the spatial profile of macular pigment (MP) density were measured for 32 subjects. Peak density of MP measured with a 460-nm, 12-arcmin stimulus averaged 0.58, standard deviation (SD) = 0.26, with a range of 0.175 to 1.39. To assess the symmetry of the MP distribution, MP density was measured on the horizontal and vertical meridians at +/-1 deg eccentricity. The density varied by no more than 16% at these four locations, indicating a basically symmetric distribution. Based on a linear interpolation between measured locations, the width of the spatial distribution of MP at half the maximal density averaged 1.03 dog, SD = 0.38, with a range of 0.25 to 1.9 deg. The average spatial profile of MP density across subjects was fitted with both an exponential and a Gaussian function. An exponential decay with eccentricity explained more variance in the data than did a Gaussian function. Assuming an exponential decay with eccentricity, once MP density has been measured in the center of the retina (denoted A), MP density at more eccentric locations (X, deg) can be predicted with a standardized equation (MP = A x 10(-0.42x)). For individual cases, small deviations from an exponential function suggest the existence of minor flanking peaks or shoulders for 40% of the subjects. We also examined the temporal stability of the MP profile of four subjects over a time span of 4-14 months and for a single spatial location for ten subjects over a time span of 1-16 years. These longitudinal data show that differences in MP density among subjects are maintained over time, if dietary patterns are stable. (C) 1997 Optical Society of America.