Natural therapeutic agents for neurodegenerative diseases from a traditional herbal medicine Pongamia pinnata (L.) Pierre
Natural therapeutic agents for neurodegenerative diseases from a traditional herbal medicine Pongamia pinnata (L.) Pierre
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来自传统草药水黄皮 (Pongamia pinnata (L.) Pierre) 的神经退行性疾病天然治疗剂
DOI：
10.1016/j.bmcl.2014.11.015
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发表时间：
2015-01-01
影响因子：
2.7
通讯作者：
Chen, Gang
中科院分区：
文献类型：
--
作者：
Li, Jiayuan;Jiang, Zhe;Chen, Gang
神经退行性疾病与神经炎症相关，表现为小胶质细胞过度产生一氧化氮（NO）。目前对神经退行性疾病仍缺乏有效的治疗和预防。针对小胶质细胞介导的神经炎症反应，对水黄皮进行了生物活性导向的植物化学研究。Pierre在本研究中进行。一种新的氯化类黄酮，2 '，6'-二甲氧基-3 '，5'-二甲氧基-[2“，3”：7，8]-呋喃酮（1）与29个已知化合物一起鉴定，其中包括黄酮类化合物（化合物2-17），（化合物18-23）、查耳酮（化合物24-25）、黄酮（化合物26-27）、三萜（化合物28-29）和生物碱（化合物30）。皮埃尔通过理化和光谱方法鉴定了它们的结构。通过测定LPS诱导的BV-2细胞NO产生来测定抗神经炎活性。然后选择pongaglabol甲醚（2）、lonchocarpin（24）和glabrachromene II（25）作为神经退行性疾病的潜在治疗剂，因为它们具有显著的抗神经炎症活性。此外，还对羽叶半夏P. pinnata（L.）分别总结了Pierre和Brief SAR。(C)2014爱思唯尔有限公司版权所有。
Neurodegenerative diseases are associated with neuroinflammation, manifested by over-production of nitric oxide (NO) by microglial cells. Now there still lack effective treatment and prevention for the neurodegenerative diseases. Concerning neuroinflammation mediated by microglia cell, bioactivity-guided phytochemical research of Pongamia pinnata (L.) Pierre was performed in this study. A new chlorinated flavonoid, 2',6'-dichlore-3', 5'-dimethoxy-[2 '',3 '': 7,8]-furanoflavone (1) was identified together with 29 known compounds, including flavonoids (compounds 2-17), isoflavonoids (compounds 18-23), chalcones (compounds 24-25), flavonones (compounds 26-27), triterpenes (28-29) and alkaloid (30) from the effective dichloride methane extract of dry stem of P. pinnata (L.) Pierre. Their structures were elucidated by physicochemical and spectral methods. The anti-neuroinflammatory activities were assayed in BV-2 cells by assessing LPS-induced NO production. Then pongaglabol methyl ether (2), lonchocarpin (24) and glabrachromene II (25) were selected as potential therapeutic agents for neurodegenerative diseases because of their significant anti-neuroinflammatory activities. Furthermore, the characteristics of structure type existing in P. pinnata (L.) Pierre and brief SAR were summarized, respectively. (C) 2014 Elsevier Ltd. All rights reserved.