Measurement of T1 and T2 in the cervical spinal cord at 3 tesla
Measurement of T1 and T2 in the cervical spinal cord at 3 tesla
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DOI：
10.1002/mrm.21596
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发表时间：
2008-07-01
影响因子：
3.3
通讯作者：
Van Zijl, Peter C. M.
中科院分区：
文献类型：
--
作者：
Smith, Seth A.;Edden, Richard A. E.;Van Zijl, Peter C. M.
在3 T条件下测量了人颈髓白色物质（WM）和灰质（GM）的T-1和T-2。使用反转恢复（IR）和双校正双翻转角梯度回波（GRE）计算T-1值，显示WM（IR = 876 +/- 27 ms，GRE = 838 +/- 54 ms）和GM（IR = 973 +/- 33 ms，GRE 994 +/- 54 ms）之间存在显著差异（p = 0.002）。IR显示侧柱和背柱WM之间存在显著差异（分别为863 +/- 23 ms和899 +/- 18 ms，p = 0.01），但GRE没有（p = 0.40）。WM（73 +/- 6 ms）和GM（76 +/- 3 ms）或外侧柱和背柱（外侧：73 +/-6 ms，背柱：72 +/- 7 ms，p = 0.59）之间的T-2无显著差异（p = 0.31）。WM弛豫时间类似于具有非常致密的纤维堆积的脑结构（例如，胼胝体），而GM值类似于脑深部GM。优化的序列参数之间的WM和GM，WM和脑脊液（CSF）之间的最大对比度。由于脊髓具有喙尾对称性，我们希望这些发现适用于整个脊髓。
T-1 and T-2 were measured for white matter (WM) and gray matter (GM) in the human cervical spinal cord at 3T. T-1 values were calculated using an inversion-recovery (IR) and Bi-corrected double flip angle gradient echo (GRE) and show significant differences (p = 0.002) between WM (IR = 876 +/- 27 ms, GRE = 838 +/- 54 ms) and GM (IR = 973 +/- 33 ms, GRE 994 +/- 54 ms). IR showed significant difference between lateral and dorsal column WM (863 +/- 23 ms and 899 +/- 18 ms, respectively, p = 0.01) but GRE did not (p = 0.40). There was no significant difference (p = 0.31) in T-2 between WM (73 +/- 6 ms) and GM (76 +/- 3 ms) or between lateral and dorsal columns (lateral: 73 +/- 6 ms, dorsal: 72 +/- 7 ms, p = 0.59). WM relaxation times were similar to brain structures with very dense fiber packing (e.g., corpus callosum), while GM values resembled deep GM in brain. Optimized sequence parameters for maximal contrast between WM and GM, and between WM and cerebrospinal fluid (CSF) were derived. Since the spinal cord has rostral-caudal symmetry, we expect these findings to be applicable to the wholecord.