MicroRNA binding site polymorphisms as biomarkers of cancer risk.
MicroRNA binding site polymorphisms as biomarkers of cancer risk.
复制标题
microRNA结合位点多态性是癌症风险的生物标志物。
DOI：
10.1586/erm.10.59
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发表时间：
2010-09
影响因子：
5.1
通讯作者：
Weidhaas JB
中科院分区：
文献类型：
--
作者：
Pelletier C;Weidhaas JB
MicroRNAs (miRNAs) are well established as global gene regulators and thus, slight alterations in miRNA levels as well as their ability to regulate their targets may cause important cellular changes leading to cancer risk. 3′ untranslated region (UTR) miRNA binding site single nucleotide polymorphisms (SNPs) have added another layer of possible genetic variation involved in the complex process of oncogenesis. Identifying these key genetically inherited effectors of miRNA functioning has improved our understanding of the complexity of disease. Interest in the field has grown rapidly in only the last 5 years, with several studies reporting on the role of 3′UTR binding site SNPs as genetic markers of increased cancer susceptibility, as well as biomarkers of cancer type, outcome and response to therapy. Currently, there are numerous known miRNA binding site SNPs associated with multiple cancer subtypes.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
6.4
作者：
Chang, Steven S.;Jiang, Wei Wen;Smith, Ian;Poeta, Luana M.;Begum, Shahnaz;Glazer, Chad;Shan, Shannon;Westra, William;Sidransky, David;Califano, Joseph A.
通讯作者：
Califano, Joseph A.
DOI：
10.1016/j.bbrc.2009.11.096
发表时间：
2010-01-01
影响因子：
3.1
作者：
Chen, Shougong;He, Yan;Gao, Yuzhen
通讯作者：
Gao, Yuzhen
影响因子：
11.2
作者：
Chin LJ;Ratner E;Leng S;Zhai R;Nallur S;Babar I;Muller RU;Straka E;Su L;Burki EA;Crowell RE;Patel R;Kulkarni T;Homer R;Zelterman D;Kidd KK;Zhu Y;Christiani DC;Belinsky SA;Slack FJ;Weidhaas JB
通讯作者：
Weidhaas JB
影响因子：
6.3
作者：
Caldwell, Stephen;Park, Sang H.
通讯作者：
Park, Sang H.