A randomised controlled trial of financial incentives to increase hepatitis B vaccination completion among people who inject drugs in Australia
A randomised controlled trial of financial incentives to increase hepatitis B vaccination completion among people who inject drugs in Australia
复制标题
DOI：
10.1016/j.ypmed.2013.04.013
复制
发表时间：
2013-10-01
影响因子：
5.1
通讯作者：
Maher, Lisa
中科院分区：
文献类型：
--
作者：
Topp, Libby;Day, Carolyn A.;Maher, Lisa
目标。本研究旨在探讨适度的经济刺激措施对提高注射吸毒者(PWID)完成3针加速乙肝疫苗接种计划(0、7、21天)的效果。随机对照试验。参与者在接种第二剂和第三剂疫苗后被随机分配到30澳元现金(“激励条件”)或标准护理(“控制条件”)。血清学确诊的对乙肝病毒敏感的PWID。两个市内医疗服务机构和一个位于澳大利亚悉尼的实地考察地点。主要结果是完成了疫苗接种系列。其他评估包括自我报告的人口统计、药物使用和治疗以及冒险历史。与对照条件相比，在意向治疗分析(n=139；87%比66%；p=.004)下，激励条件下更多的参与者在指定的窗口期内接受了所有三剂疫苗接种(n=107；92%比67%；p=.001)。多变量分析表明，激励条件和较长的注射历史显著增加了系列化完成的可能性。原住民/托雷斯海峡岛民完成这一系列的可能性显著降低。适度的经济奖励，每次注射，增加了对PWID中加速的乙肝疫苗接种时间表的遵守。这一结果对在PWID中增加乙肝病毒和其他疫苗可预防的感染具有潜在的意义。(C)2013 Elsevier Inc.保留所有权利。
Objective. This study aimed to investigate the efficacy of modest financial incentives in increasing completion of an accelerated 3-dose hepatitis B virus (HBV) vaccination schedule (0, 7, 21 days) among people who inject drugs (PWID).Methods. Randomised controlled trial. Participants were randomly allocated to receive $30 Australian Dollars cash following receipt of vaccine doses two and three ('incentive condition'), or standard care (control condition'). Serologically confirmed HBV-susceptible PWID. Two inner-city health services and a field study site in Sydney, Australia. The primary outcome was completion of the vaccination series. Additional assessments included self-reported demographic, drug use and treatment, and risk-taking histories.Results. Compared to the control condition, significantly more participants in the incentive condition received all three vaccine doses, under intention-to-treat analyses (n = 139; 87% versus 66%; p =.004); and within the specified window periods under per protocol analyses (n = 107 received three vaccine doses; 92% versus 67%; p =.001). Multivariate analysis indicated that the incentive condition and longer injecting histories significantly increased the likelihood of series completion. Aboriginal/Torres Strait Islanders were significantly less likely to complete the series.Conclusions. Modest financial incentives, per-dose, increased adherence to the accelerated HBV vaccination schedule among PWID. Results have implications for increasing HBV and, potentially, other vaccine-preventable infections, among PWID. (C) 2013 Elsevier Inc. All rights reserved.