The effect of low-dose irradiation on unstimulated and PHA-stimulated human lymphocyte subsets.
The effect of low-dose irradiation on unstimulated and PHA-stimulated human lymphocyte subsets.
复制标题
低剂量照射对未刺激和 PHA 刺激的人类淋巴细胞亚群的影响。
DOI:
10.1080/09553008814550441
复制
发表时间:
1988
期刊:
影响因子:
--
通讯作者:
Habbersett,RC
中科院分区:
文献类型:
--
作者:
Stewart,CC;Stevenson,AP;Habbersett,RC
A culture system was used to evaluate the radiosensitivity of CD 4+and CD 8+T cells, Leu 19+cells, and B cells obtained from normal adult males. Unstimulated CD 8+lymphocytes (D0= 55 cGy) were twice as radiosensitive as CD 4+cells (D0= 115 cGy). B cells had an intermediate radiosensitivity (D0= 100 cGy). Leu 19+cells were much more radioresistant and expressed aD0of 550 cGy. When lymphoid cells were irradiated 1 or 4 days before phytohemagglutinin (PHA) stimulation, they were more radiosensitive than if they were first stimulated with PHA and then irradiated. When lymphoid cells were irradiated 1 h after PHA stimulation each lymphocyte subset was characterized by an increase in theD0to 150 cGy for B cells to 290 cGy for CD4+cells, and to 240 cGy for CD8+cells. In contrast, Leu 19+cells exhibited a decrease in theirD0to 290 cGy after they were stimulated by PHA.
登录
查看更多内容
影响因子:
11.4
作者:
Peralta Eg;A. Ashkenazi;J. Winslow;Douglas H. Smith;J. Ramachandran;D. Capon
通讯作者:
D. Capon
DOI:
--
发表时间:
1986
期刊:
Life Science
影响因子:
--
作者:
Rudolf Hammer;Ettore Giraldo;G. Schiavi;Eugenia Monferini;Herbert Ladinsky
通讯作者:
Herbert Ladinsky
影响因子:
7.3
作者:
R. Barlow;K. Burston;A. Vis
通讯作者:
A. Vis
影响因子:
5
作者:
C. Schudt;C. Auriga;B. Kinder;N. Birdsall
通讯作者:
N. Birdsall
影响因子:
4.7
作者:
Ramon Diaz‐Arrastia;T. Ashizawa;S. Appel
通讯作者:
S. Appel