White Matter Hyperintensities on Brain Magnetic Resonance Imaging in People with Epilepsy: A Hospital-Based Study
White Matter Hyperintensities on Brain Magnetic Resonance Imaging in People with Epilepsy: A Hospital-Based Study
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DOI：
10.1111/cns.12571
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发表时间：
2016-09-01
影响因子：
5.5
通讯作者：
Kwan, Patrick
中科院分区：
文献类型：
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作者：
Mao, Yi-Ting;Goh, Enid;Kwan, Patrick
AimsWe的目的是探讨是否有癫痫患者增加白色高信号（WMHs）。MethodsEligible患者被归类为新诊断的癫痫（NE）和慢性癫痫（CE），后者被细分为酶诱导抗癫痫药物（EIAEDs）与或不与非酶诱导抗癫痫药物（NEIAEDs）和那些NEIAEDs只。采用年龄相关白色物质变化（ARWMC）量表测量WMH，并与健康对照组进行比较。分数越高表示WMH变化越大。协会的强度估计发病率比（IRRs）与95%的置信区间（CI）。ResultsA共217例患者被纳入分析，其中67例NE，45例CE治疗NEIAEDs，105例CE治疗EIAEDs。年龄与ARWMC评分正相关（IRR每年，1.03; 95%CI，1.03-1.04，P < 0.001）。与健康对照组（n = 23）相比，所有患者组的ARWMC评分均较高（P < 0.05）。EIAEDs组差异最大（IRR，2.13; 95%CI，1.22-3.70，P = 0.007）。患有白色物质改变的癫痫患者应评估中风风险，特别是如果他们正在接受EIAED。
AimsWe aim to explore whether people with epilepsy have increased white matter hyperintensities (WMHs).MethodsEligible patients were categorized into newly diagnosed epilepsy (NE) and chronic epilepsy (CE); the latter were subdivided to those treated with enzyme-inducing antiepileptic drugs (EIAEDs) with or without non-enzyme-inducing antiepileptic drugs (NEIAEDs) and those with NEIAEDs only. WMHs were measured using age-related white matter changes (ARWMC) scale and compared between patients and healthy control group. Higher scores indicate greater WMH changes. The strengths of associations were estimated as incidence rate ratios (IRRs) with 95% confidence interval (CI).ResultsA total of 217 patients were included in the analysis, of whom 67 had NE, 45 had CE treated with NEIAEDs, and 105 had CE treated with EIAEDs. Age was positively associated with ARWMC score (IRR per year, 1.03; 95%CI, 1.03-1.04, P < 0.001). Compared with the healthy control group (n = 23), all patient groups had higher ARWMC score (P < 0.05). The difference was greatest in patients receiving EIAEDs (IRR, 2.13; 95%CI, 1.22-3.70, P = 0.007).ConclusionsWMHs tended to be observed in people with epilepsy, especially in those treated with EIAEDs. People with epilepsy with white matter changes should be evaluated for stroke risk, particularly if they are receiving EIAEDs.