Serotonin and Serotonin Transporters in the Adrenal Medulla: A Potential Hub for Modulation of the Sympathetic Stress Response.
Serotonin and Serotonin Transporters in the Adrenal Medulla: A Potential Hub for Modulation of the Sympathetic Stress Response.
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DOI：
10.1021/acschemneuro.7b00026
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发表时间：
2017-05-17
影响因子：
5
通讯作者：
Currie KPM
中科院分区：
文献类型：
--
作者：
Brindley RL;Bauer MB;Blakely RD;Currie KPM
5-羟色胺（5-HT）是中枢神经系统中重要的神经递质，它调节涉及情绪、认知、运动、唤醒和自主神经功能的回路。5-HT转运蛋白（SERT; SLC6A4）是5-HT信号传导的关键调节因子，SERT的遗传变异与包括抑郁症、焦虑症和自闭症在内的各种疾病相关。本文就SERT在交感神经系统中的作用作一综述。自主神经/交感神经功能障碍在患有抑郁症、焦虑症和与多巴胺能信号传导相关的其他疾病的患者中是明显的。在实验上，SERT功能的丧失（SERT敲除小鼠或慢性药理学阻断）已被报道增加交感神经应激反应。CNS中的多巴胺能信号传导的改变以及因此对外周交感神经系统的中枢驱动被认为是这种增强的基础。虽然不太被广泛认识，SERT是强烈表达在肾上腺髓质，交感神经系统的神经内分泌臂的嗜铬细胞。肾上腺嗜铬细胞不合成5-HT，但通过SERT介导的摄取积累少量5-HT。最近的证据表明，5-HT 1A受体通过一种非典型机制抑制肾上腺嗜铬细胞分泌儿茶酚胺，该机制不涉及细胞兴奋性或电压门控Ca 2+通道的调节。这就提出了肾上腺髓质是交感神经应激反应的肾上腺素能控制的一个以前未被认识的外周中枢的可能性。作为一个框架，为未来的调查，提出了一个模型，其中应激诱发的肾上腺儿茶酚胺分泌的SERT调制的自分泌5-HT信号进行微调。
Serotonin (5-HT) is an important neurotransmitter in the central nervous system where it modulates circuits involved in mood, cognition, movement, arousal, and autonomic function. The 5-HT transporter (SERT; SLC6A4) is a key regulator of 5-HT signaling, and genetic variations in SERT are associated with various disorders including depression, anxiety, and autism. This review focuses on the role of SERT in the sympathetic nervous system. Autonomic / sympathetic dysfunction is evident in patients with depression, anxiety, and other diseases linked to serotonergic signaling. Experimentally, loss of SERT function (SERT knockout mice or chronic pharmacological block) has been reported to augment the sympathetic stress response. Alterations to serotonergic signaling in the CNS and thus central drive to the peripheral sympathetic nervous system are presumed to underlie this augmentation. Although less widely recognized, SERT is robustly expressed in chromaffin cells of the adrenal medulla, the neuroendocrine arm of the sympathetic nervous system. Adrenal chromaffin cells do not synthesize 5-HT but accumulate small amounts by SERT-mediated uptake. Recent evidence demonstrated that 5-HT1A receptors inhibit catecholamine secretion from adrenal chromaffin cells via an atypical mechanism that does not involve modulation of cellular excitability or voltage-gated Ca2+ channels. This raises the possibility that the adrenal medulla is a previously unrecognized peripheral hub for serotonergic control of the sympathetic stress response. As a framework for future investigation, a model is proposed in which stress-evoked adrenal catecholamine secretion is fine-tuned by SERT-modulated autocrine 5-HT signaling.
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影响因子：
4
作者：
Chan, Shyue-An;Doreian, Bryan;Smith, Corey
通讯作者：
Smith, Corey
影响因子：
5.5
作者：
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通讯作者：
Yue, DT
DOI：
10.1111/j.1460-9568.2011.07936.x
发表时间：
2012-01
期刊：
The European journal of neuroscience
影响因子：
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作者：
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通讯作者：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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