Oxygen free radicals and congestive heart failure.
Oxygen free radicals and congestive heart failure.
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DOI：
10.1136/hrt.65.5.245
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发表时间：
1991-05
影响因子：
--
通讯作者：
J. Belch;A. Bridges;N. Scott;M. Chopra
中科院分区：
文献类型：
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作者：
J. Belch;A. Bridges;N. Scott;M. Chopra
对 45 名充血性心力衰竭患者和 45 名对照者的血浆脂质过氧化物（丙二醛）和硫醇进行了测量。充血性心力衰竭患者的丙二醛浓度（中位值 9.0 nmol/ml 四分位距 (IQR) 7.9-10.2）显着高于对照组（中位值 7.7 nmol/ml (IQR 6.9-9.2)）。充血性心力衰竭患者的血浆硫醇（中位值 420 mumol/l (IQR 379-480)）显着低于对照组（中位值 463 mumol/l (IQR 445-525)）。丙二醛与左心室射血分数之间存在显着但微弱的负相关性（r = -0.35），而血浆硫醇与左心室射血分数之间存在显着但弱的正相关性（r = 0.39）。这项研究为表明自由基可能在心力衰竭中发挥重要作用的实验数据提供了临床支持。它还表明自由基产生的程度可能与疾病的严重程度有关。
Plasma lipid peroxides (malondialdehyde) and thiols were measured in 45 patients with congestive heart failure and 45 controls. Malondialdehyde concentrations were significantly higher in the patients with congestive heart failure (median 9.0 nmol/ml interquartile range (IQR) 7.9-10.2) than in the controls (median 7.7 nmol/ml (IQR 6.9-9.2)). Plasma thiols were significantly lower in congestive heart failure (median 420 mumol/l (IQR 379-480)) than in the controls (median 463 mumol/l (IQR 445-525)). There was a significant but weak negative correlation between malondialdehyde and left ventricular ejection fraction (r = -0.35) and a positive correlation between plasma thiols and left ventricular ejection fraction (r = 0.39). This study provides clinical support for experimental data indicating that free radicals may be important in heart failure. It also suggests that the degree of free radical production may be linked to the severity of the disease.