Disulfiram versus placebo for cocaine dependence in buprenorphine-maintained subjects: A preliminary trial
Disulfiram versus placebo for cocaine dependence in buprenorphine-maintained subjects: A preliminary trial
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DOI：
10.1016/s0006-3223(99)00310-8
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发表时间：
2000-06-15
影响因子：
10.6
通讯作者：
Schottenfeld, RS
中科院分区：
文献类型：
--
作者：
George, TP;Chawarski, MC;Schottenfeld, RS
Background: We examined the effects of disulfiran versus placebo on cocaine dependence in buprenorphine-maintained subjects, Methods: Opioid and cocaine dependent subjects (n = 20) were induced onto buprenorphine maintenance, then randomized to disulfiram (250 mg q.d; n = II) or placebo (n = 9) treatment for 12 weeks. Results: Groups were comparable at baseline on demographic measures and on baseline measures of drug-use severity. Fifteen subjects completed the study, including 8 subjects randomized to disulfiram (72.7%) and 7 subjects randomized to placebo (77.8%). The total number of weeks abstinent from cocaine was significantly greater on disulfiran versus placebo (mean +/- SD: 7.8 +/- 2.6 vs. 3.5 +/- 0.5, p < .05) and the number of days to achieving 3 weeks (24.6 +/- 15.1 vs. 57.8 +/- 7.7, p < .01) of continuous cocaine abstinence was significantly lower in disulfiram compared with placebo, The number of cocaine-negative urine tests during the trial were also higher on disulfiram (14.7) than on placebo 18.6); furthermore, subjects in the disulfiran,group achieved consistently higher rates of cocaine-negative urine tests in each 3-week interval and the increase over time was faster in the disulfiram compared with placebo. Conclusions: This preliminary study suggests the potential efficancy of dissulfiram versus placebo for treatment of cocaine depoendence in buprenorphine-maintained patients. Biol Psychiatry 2000;47:1080-1086 (C) 2000 Society of Biological Psychiatry.
