MicroRNA control of high-density lipoprotein metabolism and function.
MicroRNA control of high-density lipoprotein metabolism and function.
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DOI：
10.1161/circresaha.114.300645
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发表时间：
2014-01-03
影响因子：
20.1
通讯作者：
Moore KJ
中科院分区：
文献类型：
--
作者：
Rayner KJ;Moore KJ
最近发现的控制HDL丰度和功能的microrna （miRNAs）扩大了我们对这一重要脂蛋白亚类调节机制的认识。mirna已被证明可以调节控制HDL生物发生和摄取的基因网络，以及逆向胆固醇转运途径中的离散步骤。此外，HDL本身已被证明在健康和疾病中选择性地转运mirna，这为这种脂蛋白如何改变远端靶细胞和组织中的基因表达提供了新的可能性。总的来说，这些发现为HDL代谢和功能的调控机制提供了新的见解，并为心血管疾病治疗方法的开发开辟了新的途径。
Recent discoveries of microRNAs (miRNAs) that control HDL abundance and function have expanded our knowledge of the mechanisms regulating this important lipoprotein subclass. miRNAs have been shown to regulate gene networks that control HDL biogenesis and uptake, as well as discrete steps in the reverse cholesterol transport pathway. Furthermore, HDL itself has been shown to selectively transport miRNAs in health and disease, offering new possibilities of how this lipoprotein may alter gene expression in distal target cells and tissues. Collectively, these discoveries offer new insights into the mechanisms governing HDL metabolism and function, and open new avenues for the development of therapeutics for the treatment of cardiovascular disease.