The non-canonical effects of heme oxygenase-1, a classical fighter against oxidative stress.
The non-canonical effects of heme oxygenase-1, a classical fighter against oxidative stress.
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DOI：
10.1016/j.redox.2021.102170
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发表时间：
2021-11
期刊：
影响因子：
11.4
通讯作者：
Hui Y
中科院分区：
文献类型：
--
作者：
Wu J;Li S;Li C;Cui L;Ma J;Hui Y
血红素氧合酶-1在抗氧化应激和细胞保护中的作用一直是研究热点。随着研究的不断深入，HO-1蛋白除了通过催化血红素降解直接调节氧化还原外，还以多种方式参与基因表达水平，从而启动细胞防御。特别是非典型的核定位HO-1和HO-1蛋白的相互作用发挥了对抗氧化应激的战士的作用。此外，HO-1在许多临床试验中可能是一种有前途的疾病预测和检测标志物。特别是对于恶性疾病，HO-1通过调节异常ROS和代谢信号传导的治疗可能会有新的进展。本文旨在对几个方面的研究进行系统的梳理和描述，以利于今后进一步详细的机制研究和临床应用推广。HO-1的不同亚细胞定位暗示其具有特殊的功能。细胞核HO-1在基因调控等方面发挥着不可或缺的作用。HO-1与其他分子之间的相互作用为参与重要的生理过程提供了可能性。HO-1可能成为一种潜在的疾病评估标志物。
The role of heme oxygenase-1 in resisting oxidative stress and cell protection has always been a hot research topic. With the continuous deepening of research, in addition to directly regulating redox by catalyzing the degradation of heme, HO-1 protein also participates in the gene expression level in a great diversity of methods, thereby initiating cell defense. Particularly the non-canonical nuclear-localized HO-1 and HO-1 protein interactions play the role of a warrior against oxidative stress. Besides, HO-1 may be a promising marker for disease prediction and detection in many clinical trials. Especially for malignant diseases, there may be new advances in the treatment of HO-1 by regulating abnormal ROS and metabolic signaling. The purpose of this review is to systematically sort out and describe several aspects of research to facilitate further detailed mechanism research and clinical application promotion in the future. The different subcellular localizations ofHO-1 implies that it has special functions. Nuclear HO-1 plays an indispensable role in gene regulation and other aspects. The interactions between HO-1 and others provide the possibility to participate in vital physiological processes. HO-1 may become a potential disease assessment marker.
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